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OverviewTranscriptional gene silencing enables multi-cellular eukaryotes to achieve differential gene expression during differentiation. In plants and mammals, silent chromatin is associated with hypermethylation of DNA at CpG sites and methylation of histone H3 at lysine 9 (H3K9-met). These covalent modifications attract specific chromatin binding factors and ensure faithful inheritance of gene expression patterns during DNA replication and mitosis, referred as epigenetic inheritance. Importantly, chromatin factors which act independent of DNA methylation in maintenance of heritable gene silencing are also known in Arabidopsis. The intricate relationship between DNA methylation, H3K9-met and chromatin binding factors is under intense scrutiny to understand epigenetic inheritance. This book reveals a complex inter-play between DNA and H3K9 methylation deciphered in Arabidopsis. In addition it also reveals how epigenetic silencing can be reversed without passage through S phase of cell cycle. This concludes that epigenetic plasticity enables cells to survive constantly changing environment during differentiation when chromatin is subject to dynamic regulation. Full Product DetailsAuthor: MUHAMMAD TARIQPublisher: VDM Verlag Dr. Muller Aktiengesellschaft & Co. KG Imprint: VDM Verlag Dr. Muller Aktiengesellschaft & Co. KG Dimensions: Width: 22.90cm , Height: 0.60cm , Length: 15.20cm Weight: 0.182kg ISBN: 9783639256734ISBN 10: 3639256735 Pages: 116 Publication Date: 13 May 2010 Audience: General/trade , General Format: Paperback Publisher's Status: Active Availability: In Print  This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of ContentsReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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