Overview

DNA methylation is essential for the normal development and functioning of organisms. This volume discusses the latest developments in this very active field of research. It presents the evolution of DNA methylation, mammalian DNA methyltransferases, DNA methylation and demethlyation, DNA methylation and silencing and the role it plays in medicine including cancer.

Full Product Details

Author:   Xiaodong Cheng (Emory University School of Medicine, Atlanta, GA, USA) ,  Robert M. Blumenthal (The University of Toledo College of Medicine, OH, USA)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Volume:   101
Weight:   0.810kg
ISBN:  

9780123876850

ISBN 10:   0123876850
Pages:   502
Publication Date:   02 June 2011
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

1. Introduction – Epiphanies in Epigenetics Xiaodong Cheng and Robert M. Blumenthal Section I. EVOLUTION OF DNA METHYLATION 2. The natural history of eukaryotic DNA methylation systems Lakshminarayan M. Iyer, Saraswathi Abhiman, L. Aravind 3. Evolution of histone methyltransferases and demethylases L. Aravind 4. DNA methylation in Drosophila – A critical evaluation Veiko Krauss and Gunter Reuter 5. DNA Methylation in Zebrafish Mary G Goll and Marnie E Halpern Seciton II. MAMMALIAN DNA METHYLTRANSFERASES – STRUCTURE AND FUNCTION 6. Dnmt1 - structure and function Željko M. Svedružic 7. The DNMT3 family of MAMMALIAN de novo DNA methyltransferases Frédéric Chédin Seciton III. DNA METHYLATION AND DEMETHYLATION 8. Recruitment of Dnmt1: Roles of the SRA protein Np95 (Uhrf1) and other factors Jafar Sharif & Haruhiko Koseki 9. Regulation of Expression and Activity of DNA (cytosine-5) methyltransferases in mammalian cells Shannon R. Morey Kinney and Sriharsa Pradhan 10. Mechanistic and functional links between histone methylation and DNA methylation Taiping Chen Section IV. DNA METHYLATION IN MEDICINE 11. RNA mediated silencing mechanisms in mammalian cells Anton Wutz 12. Biological functions of methyl-CpG binding proteins Pierre-Antoine Defossez and Irina Stancheva Section V. DNA METHYLATION IN MEDICINE 13. Diseases associated with imprinting J.F. Wilkins and F. Úbeda 14. DNA methylation changes in cancer Minoru Toyota and Eiichiro Yamamoto 15. Epigenetic biomarkers J. Tost 16. Distribution of methylation at the single-nucleotide level E. 

Reviews

PRAISE FOR THE SERIES Full of interest not only for the molecular biologist--for whom the numerous references will be invaluable--but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell. --British Medical Journal

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