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OverviewMolecular biology has rapidly advanced since the discovery of the basic flow of information in life, from DNA to RNA to proteins. While there are several important and interesting exceptions to this general flow of information, the importance of these biological macromolecules in dictating the phenotypic nature of living creatures in health and disease is paramount. In the last one and a half decades, and particularly after the completion of the Human Genome Project, there has been an explosion of technologies that allow the broad characterization of these macromolecules in physiology, and the perturbations to these macromolecules that occur in diseases such as cancer. In this volume, we will explore the modern approaches used to characterize these macromolecules in an unbiased, systematic way. Such technologies are rapidly advancing our knowledge of the coordinated and complicated changes that occur during carcinogenesis, and are providing vital information that, when correctly interpreted by biostatistical/bioinformatics analyses, can be exploited for the prevention, diagnosis, and treatment of human cancers. The purpose of this volume is to provide an overview of modern molecular biological approaches to unbiased discovery in cancer research. Advances in molecular biology allowing unbiased analysis of changes in cancer initiation and progression will be overviewed. These include the strategies employed in modern genomics, gene expression analysis, and proteomics. Full Product DetailsAuthor: Srinivasan Yegnasubramanian , William B. IsaacsPublisher: Springer-Verlag New York Inc. Imprint: Springer-Verlag New York Inc. Edition: 2010 ed. Dimensions: Width: 15.50cm , Height: 1.10cm , Length: 23.50cm Weight: 0.320kg ISBN: 9781461426578ISBN 10: 146142657 Pages: 192 Publication Date: 05 November 2012 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: Manufactured on demand ![]() We will order this item for you from a manufactured on demand supplier. Table of ContentsGenome-Scale Analysis of Data from High-Throughput Technologies.- Analysis of Inherited and Acquired Genetic Variation.- Examining DNA–Protein Interactions with Genome-Wide Chromatin Immunoprecipitation Analysis.- Genome-Wide DNA Methylation Analysis in Cancer Research.- Use of Expression Microarrays in Cancer Research.- Signal Sequencing for Gene Expression Profiling.- Mass Spectrometry Based Proteomics in Cancer Research.- Tissue Microarrays in Cancer Research.ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |