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OverviewThis book summarizes recent advances in understanding the mechanism underlying the selective cell death of dopamine neurons in Parkinson's disease. MPTP, endogenous neurotoxins, L-DOPA, and metal were proved to induce apoptosis and necrosis in neurons. The relationship of these causal factors to the pathogenesis of Parkinson's disease was discussed to give overviews on the role of neurotoxins in this degenerative disorder. This title further presents the intracellular signal transduction, and the related enzymes and other factors involved in dopaminergic neuronal death. Recent results on intracellular mechanism of neuroprotection are presented, suggesting that neuroprotection as a causal therapy of neurodegenerative disorders may become practical in near future. This book shows new neuroprotective agents, such as propargylamine derivatives and neurotrophins, and the intracellular mechanism to prevent the activation of apoptotic cascade in neurons. The authors of this book are active researchers participating in these subjects and the readers will find the knowledge and techniques for the study on neurotoxicity and neuroprotection, and the strategy for future research on these important subjects in clinical and basic neurology and neurosciences. The book is dedicated to Professor Toshiharu Nagatsu, a pioneer in the search for pathogenic factors in Parkinson's disease. The book is reprinted from the journal 'Neurotoxicology and Teratology', Volume 24/5. Full Product DetailsAuthor: M. Naoi (Department of Brain Sciences, Institute of Applied Biochemistry, Yagi Memorial Park, Mitake, Kani-gum, Gifu, Japan) , W. Maruyama (Laboratory of Biochemistry & Metabolism, Department of Basic Gerontology, National Institute for Longevity Science, Obu, Japan) , M.A. Collins (Department of Biochemistry, Loyola University Medical Center, Maywood, IL, USA) , M B H Youdim (Rappaport Medical Institute, Department of Pharmacology, Technion, Faculty of Medicine, Haifa, Israel)Publisher: Elsevier Science & Technology Imprint: Elsevier Science Ltd Dimensions: Width: 21.00cm , Height: 0.60cm , Length: 27.90cm Weight: 0.650kg ISBN: 9780444510365ISBN 10: 0444510362 Pages: 154 Publication Date: 25 September 2002 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: Out of stock  The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available. Table of Contents"Laudatio. Conformational diseases: Misfolding mechanisms may pave the way to early therapy (C. Reiss et al.). Editorial. Tribute to Professor Toshiharu Nagatsu (M. Naoi et al.). Reviews. Amine-related neurotoxins in Parkinson's disease: Past, present, and future (T. Nagatsu). Potential neurotoxic ""agents provocateurs"" in Parkinson's disease (M.A. Collins et al.). Dopamine-derived endogenous N-methyl-(R)-salsolinol: Its role in Parkinson's disease (M. Naoi et al.). N-methylation underlying Parkinson's disease (K. Matsubara et al.). Apoptotic molecules and MPTP-induced cell death (A. Nicotra, S.H. Parvez). MPTO: Insights into parkinsonian neurodegeneration (S.G. Speciale). Influence of neuromelanin on oxidative pathways within the human substantia nigra (K.L. Double et al.). DOPA causes glutamate release and delayed neuron death by brain ischemia in rats (Y. Misu et al.). Manganese-induced apoptosis in PC12 cells (Y. Hirata). Physiological role of salsolinol: Its hypophysiotrophic function in the regulation of pituitary prolactin secretion (B.E. Töth et al.). Aliphatic propargylamines as symptomatic and neuroprotective treatments for neurodegenerative diseases (M.D. Berry, A.A. Boulton). Neuroprotection by propargylamines in Parkinson's disease: Suppression of apoptosis and induction of prosurvival genes (W. Maruyama et al.). Docosahexaenoic acid attenuated hypertension and vascular dementia in stroke-prone spontaneously hypertensive rats (S. Kimura et al.). Diabetic neuropathies in brain are induced by deficiency of BDNF (A. Nitta et al.)."ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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