Overview

Microsatellites are short stretches of repeated DNA, found in most genomes, that show exceptional variability in humans and most other species. This variability has made microsatellites the genetic marker of choice for most applications, including genetic mapping and studies of the evolutionary connections between species and populations. This book brings together an international group of scientists currently working in microsatellites. Their contributions provide a detailed description of microsatellite biology, focusing on their mutation properties, generation, decay, and possible functional roles. They introduce the theoretical models that underpin the most popular methods for analysing the information that microsatellites can yield, including methods for estimating coalescent times, population divergences, and migration. Finally, the book describes the various ways in which the potential of microsatellites is being harnessed in a range of applications including medical genetics, forensics, genetic mapping, the analysis of human evolution, and conservation genetics.

Full Product Details

Author:   David B. Goldstein (, University College London) ,  Christian Schlotterer (Institut für Tiersucht und Genetik, Institut für Tiersucht und Genetik, Veterinamedizinische Universitat, Vienna)
Publisher:   Oxford University Press
Imprint:   Oxford University Press
Dimensions:   Width: 15.70cm , Height: 2.00cm , Length: 23.50cm
Weight:   0.553kg
ISBN:  

9780198504078

ISBN 10:   0198504071
Pages:   368
Publication Date:   10 June 1999
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   To order  
Stock availability from the supplier is unknown. We will order it for you and ship this item to you once it is received by us.

Table of Contents

1: Hancock: Microsatellites and other simple sequences 2: Kashi and Soller: Functional roles of microsatellites and minisatellites 3: Armour et al: Microsatellites and mutation processes in tandemly repetitive DNA 4: Eisen: Mechanistic basis for microsatellite instability 5: Estoup and Cornuet: Microsatellite evolution : inferences from population data 6: Amos: A comparative approach to the study of microsatellite evolution 7: Rubinsztein: Trinucleotide expansion mutations cause diseases which do not conform to Mendelian expectations 8: Feldman: Mutation and migration in models of microsatellite evolution 9: Donnelly: The coalescent and microsatellite variability 10: Reich and Goldstein: Estimating the age of mutations using variation of linked markers 11: Chakraborty and Kimmel: Statistics of microsatellite loci : Estimation of mutation rate and pattern of population expansion 12: Pemberton et al: Using microsatellites to measure the fitness consequences of inbreeding and outbreeding 13: Beaumont and Bruford: Microsatellites in conservation genetics 14: Linares: Microsatellites and the reconstruction of the history of human populations 15: Balding: Forensic applications of microsatellite markers 16: Stephens et al: Tracking linkage disequilibrium in advanced population with microsatellite loci 17: Carrington et al: Microsatellite markers in complex disease : mapping disease - associated regions within the human MHC 18: Schlotterer and Wiehe: Microsatellites : a neutral marker to infer selective sweeps 19: Karafet et al: Y chromosome microsatellite haplotypes and the history of Samoyed-speaking populations in N-W Siberia 20: Shibata: MS analysis of human tumours

Reviews

This excellent book makes a strong case for microsatellites...several of the book's editors and contributors have been active in developing these genetic distance measures. This book will provide an excellent introduction and reference for those using tandem repeats in their research. -- The Quarterly Review of Biology, Vol 76, Mar 2001<br>

<br> This excellent book makes a strong case for microsatellites...several of the book's editors and contributors have been active in developing these genetic distance measures. This book will provide an excellent introduction and reference for those using tandem repeats in their research. -- The Quarterly Review of Biology, Vol 76, Mar 2001<br>

'...Packed with need to know facts, well illustrated and not overburdened by technical jargon, the editors should be congratulated for having had the foresight to assemble 20 chapters, each by acting leading experts in their field, which must become a standard reference work' The Genetical Society Great Britain '...It is the most comprehensive volume on microsatellities and has contributions from many excellent researchers' TREE

Author Information

David B Goldstein, Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS david.goldstein@zoo.ox.ac.uk Christian Schlötterer, Institut für Tierzucht und Genetik, Veterinärmedizinische Universität Wien, Vienna, Austria christian.schloetterer@vu-wien.ac.at

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