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OverviewMicroarray is an important technology which enables people to investigate the expression levels of thousands of genes at the same time. A series of methods are proposed in this book to to detect differentially expressed genes while controlling the false discovery rate. In Chapter 1 and 2, a brief introduction of the Affymetrix GeneChip microarray technology and a literature review of the related works on this matter is provided.In Chapter 3, a t-mixture model based method is proposed to detect differentially expressed genes. In Chapter 4, a t-mixture model based false discovery rate estimator is proposed to overcome several problems of the current empirical false discovery rate estimators. In Chapter 5, a two-step false discovery rate estimation procedure is proposed to correct the overestimation of the false discovery rate caused by differentially expressed genes. In Chapter 6, a novel estimator is developed to estimate the proportion of equivalently expressed genes, which is an important component of the false discovery rate estimators. Full Product DetailsAuthor: Shuo JiaoPublisher: VDM Verlag Dr. Muller Aktiengesellschaft & Co. KG Imprint: VDM Verlag Dr. Muller Aktiengesellschaft & Co. KG Dimensions: Width: 22.90cm , Height: 0.70cm , Length: 15.20cm Weight: 0.199kg ISBN: 9783639238099ISBN 10: 3639238095 Pages: 128 Publication Date: 07 March 2010 Audience: General/trade , General Format: Paperback Publisher's Status: Active Availability: In Print This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of ContentsReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |