Overview

Cancer is the leading cause of death, in the number of older cancer patients is after cardiovascular diseases, in the expected. Approximately, 77% of all types United States. A total of ? 1,399,790 new of cancers are diagnosed in persons of 55 cancer cases and ? 564,830 deaths were years and older. It was estimated that o- reported in the year 2006 in the country. third of the 559,650 cancer deaths in 2007 Approximately, one in every two men and in the United States were related to ov- one in every three women in the country weight or obesity, physical inactivity, and will have some type of cancer during nutrition, and thus could also be prevented their lifetime. Healthcare costs exceed (Am. Cancer Society, 2007). However, 1. 7 trillion dollars per year in the United in developed countries, including United States, which is ? 15% of the country’s States, the average person of 65 years can gross domestic product. expect to live another 15 years in a fairly Tobacco use is the most serious prevent- good health. Persons of 75 or 85 years old able cause of cancer. Tobacco use causes have an average expectancy of 10 and 6 cancer of the lung, throat, mouth, pancreas, years, respectively. urinary bladder, stomach, liver, kidney, and During the last three decades, intensive other types. Passive smoking causes lung clinical research has resulted in reduced cancer.

Full Product Details

Author:   M. A. Hayat
Publisher:   Springer
Imprint:   Springer
Edition:   Softcover reprint of hardcover 1st ed. 2009
Volume:   2
Weight:   1.555kg
ISBN:  

9789048178834

ISBN 10:   9048178835
Pages:   602
Publication Date:   30 November 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Out of stock  
The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available.

Table of Contents

PART I GENERAL METHODS AND OVERVIEWS 1.1. METABOLIC TRANSFORMATIONS OF MALIGNANT CELLS (AN OVERVIEW) Leslie C. Costello and Renty B. Franklin INTRODUCTION DEFINING A MALIGNANT CELL: A PARASITIC EXISTENCE THE IN SITU ENVIRONMENT OF THE MALIGNANT CELL DICTATES ITS METABOLISM TUMOR CELL PROLIFERATION: METABOLIC PATHWAYS FOR ITS ACHIEVEMENT COUPLING OF GLYCOLYSIS VIA CITRATE TO DE NOVO LIPOGENESIS/CHOLESTEROGENESIS OPERATION OF THE KREBS CYCLE IN TUMOR CELLS GLUTAMINOLYSIS AS AN ALTERNATE OR ADDITIONAL PATHWAY IN TUMOR CELLS OPERATION OF THE KREBS CYCLE IN TUMOR CELLS APPLICATION OF MOLECULAR GENETICS AND PROTEOMICS TO TUMOR CELL INTERMEDIARY METABOLISM ACKNOWLEDGEMENT REFERENCES 1.2. IMAGING TO DETECT RECURRENT CANCER S.J. Gwyther INTRODUCTION LUNG CANCER BREAST CANCER COLORECTAL CANCER LYMPHOMAS PANCREATIC CANCER PROSTATE CANCER GYNECOLOGICAL CANCERS Ovarian Cancer Endometrial Cancer Cervical Cancer HEAD AND NECK CANCERS THYROID CANCER RENAL AND BLADDER TUMORS PRIMARY INTRACRANIAL TUMORS CONCLUSIONS REFERENCES 1.3. TUMOR GENE THERAPY: MAGNETIC RESONANCE IMAGING AND MAGNETIC RESONANCE SPECTROSCOPY Mikko I. Kettunen and Olli H.J. Grohn INTRODUCTION TUMOR GENE THERAPY MAGNETIC RESONANCE IMAGING Endogenous Magnetic Resonance Imaging Contrast Exogenous Contrast Agents MAGNETIC RESONANCE SPECTROSCOPY DETECTION OF TRANSGENE DELIVERY AND EXPRESSION USING MAGNETIC RESONANCE IMAGING AND SPECTROSCOPY DETECTION OF GENE THERAPY RESPONSE USING MAGNETIC RESONANCE IMAGING AND SPECTROSCOPY Volumetric Imaging Endogenous Contrasts Sodium Magnetic Resonance Imaging Molecular Imaging Magnetic Resonance Spectroscopy of Metabolic Alterations SUMMARY REFERENCES 1.4. ASSESSMENT OF GENE TRANSFER: MAGNETIC RESONANCE IMAGING AND 18F-FLUORODEOXYGLUCOSE POSITRON EMISSION TOMOGRAPHY Annette Altman and Uwe Haberkorn INTRODUCTION MOLECULAR IMAGING MODALITIES FOR GENE EXPRESSION MOLECULAR IMAGING OF SUICIDE GENE TRANSFER AND THERAPEUTIC EFFECTS MOLECULAR IMAGING SUBSTRATE UPTAKE AFTER SUICIDE GENE TRANSDUCTION NONINVASIVE IMAGING OF REPORTER GENE TRANSFER REFERENCES 1.5. ROLE OF MUTATIONS IN TP53 IN CANCER (AN OVERVIEW) Franck Toledo INTRODUCTION IMPACT OF TP53 MUTATIONS ON P53 TRANSACTIVATION CAPACITY OTHER EFFECTS OF TP53 MUTATIONS TP53 MUTATIONS AND THE ETIOLOGY OF HUMAN CANCERS PROGNOSTIC AND PREDICTIVE VALUE OF TP53 MUTATIONS CORRECTION OF P53 PATHWAY IN TUMORS FUTURE PERSPECTIVES REFERENCES 1.6. PERSONALIZED CANCER MEDICINE (AN OVERVIEW) Sarah J. Welsh and Garth Powis INTRODUCTION WHY IS PERSONALIZED MEDICINE IMPORTANT IN CANCER? TO WHAT EXTENT IS CANCER MEDICINE ALREADY PERSONALIZED? FUTURE OF PERSONALIZED MEDICINE IN CANCER CHALLENGES FOR ACHIEVING PERSONALIZED MEDICINE REFERENCES 1.7. RADIATION DOSES TO PATIENTS USING COMPUTED RADIOGRAPHY, DIRECT DIGITAL RADIOGRAPHY, AND SCREEN-FILM RADIOGRAPHY Gaetano Compagnone INTRODUCTION RADIATION QUANTITIES USED IN PATIENT DOSIMETRY CONVENTIONAL SCREEN-FILM SYSTEMS PATIENT DOSE AND IMAGE QUALITY WITH CONVENTIONAL SCREEN-FILM SYSTEMS COMPUTED RADIOGRAPHY PATIENT DOSE AND IMAGE QUALITY WITH COMPUTED RADIOGRAPHY DIRECT DIGITAL RADIOGRAPHY PATIENT DOSE AND QUALITY WITH DIRECT DIGITAL RADIOGRAPHY CONCLUSIONS REFERENCES 1.8. CANCER VACCINES AND IMMUNE MONITORING (AN OVERVIEW) Zsuzsanna Tabi and Stephen Man INTRODUCTION PROPHYLACTIC CANCER VACCINES Vaccines

Reviews

Once more Professor Hayat has to be congratulated for bringing together 56 leading scientists representing 16 countries in the field of breast cancer, which has made it possible to publish such an excellent book. It represents a valuable addition to the available literature on breast cancer treatment since it covers all aspects of breast cancer, including diagnosis, treatments, and prognosis. Thereby, not only efficacy of various anticancer drugs and their side-effects are pointed out, but also the necessity of age-dependent breast cancer strategies is highlighted. Therefore, I conclude that this book is a true benefit to all clinicians, surgeons, and oncologists working in the field of breast cancer. Professor Dr. Thomas Dittmer Institute of Immunology Witten/Herdecke University Witten, Germany This first volume of the Handbook on Methods of Cancer Diagnosis, Therapy, and Prognosis, concerns problems related to diagnosis, treatment, monitoring of therapy, and prognosis in breast cancer. This is an impressive monograph containing data range on novel techniques (e.g., PET examination of sentinel lymph nodes) used in early diagnosis, prognosis (Molecular studies on circulating neoplastic cells), and treatment (surgery, chemo-radio-and hormontherapy) of various histological types of breast cancer. This monograph resulting from cooperative efforts of 56 authors from 16 countries (specialists in this field) cannot be matched by any publication of this type. The oncologists, pathologists, and scientists engaged in problems of breast cancer should have this extremely valuable Handbook at hand. Professor Piotr Dziegiel Department of Histology and Embryology Medical University of Wroclaw, Poland It has been a great pleasure to review the forthcoming book, Methods of Cancer Diagnosis, Therapy, and Prognosis: Volume 1, edited by Professor M.A. Hayat. Dr. Hayat is a Distinguished Professor in the Department of Biological Sciences, Kean University, Union, New Jersey. After seeing the chapters listed in his book, I am very impressed by the thoroughness of the topics in the proposed book. As an editor, Dr. Hayat has assembled a group of well known researchers and clinicians from many parts of the world to write the state-of-the art chapters on breast cancer, including but not limited to the chapters, on computer-assisted diagnosis, familial breast cancer, serum markers in diagnosis, circulating cancer cells before and after treatments, epigenetic markers, metastasis and its detection, validation of biomarkers, immunohistochemistry, invasive cancer and treatments. He has summarized the problems associated with the complexities of research publications which are not easy reading even for many scientists and clinicians. The subject matter is, undoubtedly, complex and formidable for many breast cancer patients. The current consolidated information on breast cancer research is not readily available. The numbers of cancer cases are projected to increase significantly by 2030, especially in low and middle income countries. Even in the advanced countries, there is a population of low and middle income people who do not have access to appropriate diagnosis and treatment. These people suffer from the same problems as those belonging to the low and middle income countries. Dr. Hayat has provided data in his preface showing that some cancers can be reduced by changes in lifestyle and education. His assessment is very timely. With best wishes and regards to Dr. Hayat. Akhouri A. Sinha, Ph.D. Professor of Genetics, Cell Biology and Development, The University of Minnesota and Research Scientist at the Veterans Affairs Medical Center, Minneapolis, Minnesota. Professor Hayat has done it again! He has edited (METHODS OF CANCER DIAGNOSIS, THERAPY, AND PROGNOSIS, to be published by Springer) a comprehensive treatise on diagnosis, therapy, recurrence, resistance along with risk benefit ratio in cancers with special emphasis on breast cancer. Scientists and clinicians from the world over have contributed the latest advances in their respective areas of expertise. The reader is provided with a whole field view of the state of the art in breast cancer management. This treatise will serve as a must read for oncologists, scientist researchers and students of cancer biology. I look forward to the next series dealing with epidemiology, genetic predisposition and the role of the tumor microenvironment in cancer biology. Debabrata Banerjee Ph.D Associate Professor Medicine and Pharmacology Cancer Institute of New Jersey, New Brunswick

Once more Professor Hayat has to be congratulated for bringing together 56 leading scientists representing 16 countries in the field of breast cancer, which has made it possible to publish such an excellent book. It represents a valuable addition to the available literature on breast cancer treatment since it covers all aspects of breast cancer, including diagnosis, treatments, and prognosis. Thereby, not only efficacy of various anticancer drugs and their side-effects are pointed out, but also the necessity of age-dependent breast cancer strategies is highlighted. Therefore, I conclude that this book is a true benefit to all clinicians, surgeons, and oncologists working in the field of breast cancer. Professor Dr. Thomas DittmerInstitute of ImmunologyWitten/Herdecke UniversityWitten, Germany This first volume of the Handbook on Methods of Cancer Diagnosis, Therapy, and Prognosis, concerns problems related to diagnosis, treatment, monitoring of therapy, and prognosis in breast cancer. This is an impressive monograph containing data range on novel techniques (e.g., PET examination of sentinel lymph nodes) used in early diagnosis, prognosis (Molecular studies on circulating neoplastic cells), and treatment (surgery, chemo-radio-and hormontherapy) of various histological types of breast cancer. This monograph resulting from cooperative efforts of 56 authors from 16 countries (specialists in this field) cannot be matched by any publication of this type. The oncologists, pathologists, and scientists engaged in problems of breast cancer should have this extremely valuable Handbook at hand. Professor Piotr DziegielDepartment of Histology and EmbryologyMedical University of Wroclaw, Poland It has been a great pleasure to review the forthcoming book, Methods of Cancer Diagnosis, Therapy, and Prognosis: Volume 1, edited by Professor M.A. Hayat. Dr. Hayat is a Distinguished Professor in the Department of Biological Sciences, Kean University, Union, New Jersey. After seeing the chapters listed in his book, I am very impressed by the thoroughness of the topics in the proposed book. As an editor, Dr. Hayat has assembled a group of well known researchers and clinicians from many parts of the world to write the state-of-the art chapters on breast cancer, including but not limited to the chapters, on computer-assisted diagnosis, familial breast cancer, serum markers in diagnosis, circulating cancer cells before and after treatments, epigenetic markers, metastasis and its detection, validation of biomarkers, immunohistochemistry, invasive cancer and treatments. He has summarized the problems associated with the complexities of research publications which are not easy reading even for many scientists and clinicians. The subject matter is, undoubtedly, complex and formidable for many breast cancer patients. The current consolidated information on breast cancer research is not readily available. The numbers of cancer cases are projected to increase significantly by 2030, especially in low and middle income countries. Even in the advanced countries, there is a population of low and middle income people who do not have access to appropriate diagnosis and treatment. These people suffer from the same problems as those belonging to the low and middle income countries. Dr. Hayat has provided data in his preface showing that some cancers can be reduced by changes in lifestyle and education. His assessment is very timely. With best wishes and regards to Dr. Hayat. Akhouri A. Sinha, Ph.D. Professor of Genetics, Cell Biology and Development, The University of Minnesota and Research Scientist at the Veterans Affairs Medical Center, Minneapolis, Minnesota. Professor Hayat has done it again! He has edited (METHODS OF CANCER DIAGNOSIS, THERAPY, AND PROGNOSIS, to be published by Springer) a comprehensive treatise on diagnosis, therapy, recurrence, resistance along with risk benefit ratio in cancers with special emphasis on breast cancer. Scientists and clinicians from the world over have contributed the latest advances in their respective areas of expertise. The reader is provided with a whole field view of the state of the art in breast cancer management. This treatise will serve as a must read for oncologists, scientist researchers and students of cancer biology. I look forward to the next series dealing with epidemiology, genetic predisposition and the role of the tumor microenvironment in cancer biology. Debabrata Banerjee Ph.DAssociate ProfessorMedicine and PharmacologyCancer Institute of New Jersey, New Brunswick

Once more Professor Hayat has to be congratulated for bringing together 56 leading scientists representing 16 countries in the field of breast cancer, which has made it possible to publish such an excellent book. It represents a valuable addition to the available literature on breast cancer treatment since it covers all aspects of breast cancer, including diagnosis, treatments, and prognosis. Thereby, not only efficacy of various anticancer drugs and their side-effects are pointed out, but also the necessity of age-dependent breast cancer strategies is highlighted. Therefore, I conclude that this book is a true benefit to all clinicians, surgeons, and oncologists working in the field of breast cancer. Professor Dr. Thomas Dittmer Institute of Immunology Witten/Herdecke University Witten, Germany This first volume of the Handbook on Methods of Cancer Diagnosis, Therapy, and Prognosis, concerns problems related to diagnosis, treatment, monitoring of therapy, and prognosis in breast cancer. This is an impressive monograph containing data range on novel techniques (e.g., PET examination of sentinel lymph nodes) used in early diagnosis, prognosis (Molecular studies on circulating neoplastic cells), and treatment (surgery, chemo-radio-and hormontherapy) of various histological types of breast cancer. This monograph resulting from cooperative efforts of 56 authors from 16 countries (specialists in this field) cannot be matched by any publication of this type. The oncologists, pathologists, and scientists engaged in problems of breast cancer should have this extremely valuable Handbook at hand. Professor Piotr Dziegiel Department of Histology and Embryology Medical University of Wroclaw, Poland It has been a great pleasure to review the forthcoming book, Methods of Cancer Diagnosis, Therapy, and Prognosis: Volume 1, edited by Professor M.A. Hayat. Dr. Hayat is a Distinguished Professor in the Department of Biological Sciences, Kean University, Union, New Jersey. After seeing the chapters listed in his book, I am very impressed by the thoroughness of the topics in the proposed book. As an editor, Dr. Hayat has assembled a group of well known researchers and clinicians from many parts of the world to write the state-of-the art chapters on breast cancer, including but not limited to the chapters, on computer-assisted diagnosis, familial breast cancer, serum markers in diagnosis, circulating cancer cells before and after treatments, epigenetic markers, metastasis and its detection, validation of biomarkers, immunohistochemistry, invasive cancer and treatments. He has summarized the problems associated with the complexities of research publications which are not easy reading even for many scientists and clinicians. The subject matter is, undoubtedly, complex and formidable for many breast cancer patients. The current consolidated information on breast cancer research is not readily available. The numbers of cancer cases are projected to increase significantly by 2030, especially in low and middle income countries. Even in the advanced countries, there is a population of low and middle income people who do not have access to appropriate diagnosis and treatment. These people suffer from the same problems as those belonging to the low and middle income countries. Dr. Hayat has provided data in his preface showing that some cancers can be reduced by changes in lifestyle and education. His assessment is very timely. With best wishes and regards to Dr. Hayat. Akhouri A. Sinha, Ph.D. Professor of Genetics, Cell Biology and Development, The University of Minnesota and Research Scientist at the Veterans Affairs Medical Center, Minneapolis, Minnesota. Professor Hayat has done it again! He has edited (METHODS OF CANCER DIAGNOSIS, THERAPY, AND PROGNOSIS, to be published by Springer) a comprehensive treatise on diagnosis, therapy, recurrence, resistance along with risk benefit ratio in cancers with special emphasis on breast cancer. Scientists and clinicians from the world over have contributed the latest advances in their respective areas of expertise. The reader is provided with a whole field view of the state of the art in breast cancer management. This treatise will serve as a must read for oncologists, scientist researchers and students of cancer biology. I look forward to the next series dealing with epidemiology, genetic predisposition and the role of the tumor microenvironment in cancer biology. Debabrata Banerjee Ph.D Associate Professor Medicine and Pharmacology Cancer Institute of New Jersey, New Brunswick

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