Overview

The current volume provides detailed experimental protocols used to study plasma membrane ion channels as pharmacological targets. Coverage includes molecular and biochemical characterization of ion channels; fuctional analysis of ion channels after reconstitution, expression, or in cells; and specific methods and tools. This wealth of information will benefit academic and industrial researchers and graduate students in pharmacology, biochemistry, physiology, and biophysics.

Full Product Details

Author:   H. Glossmann ,  J. Striessnig
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   Softcover reprint of hardcover 1st ed. 1993
Dimensions:   Width: 17.80cm , Height: 1.50cm , Length: 25.40cm
Weight:   0.559kg
ISBN:  

9781441932327

ISBN 10:   1441932321
Pages:   278
Publication Date:   29 October 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

I Molecular and Biochemical Characterization of Ion Channels.- 1 Purification and Pharmacological Analysis of the Omega-Conotoxin GVIA Receptor from Rat Brain.- 2 Molecular Characterization of the Charybdotoxin-Sensitive, High-Conductance, Calcium-Activated Potassium Channel.- 3 Characterization of the Sulfonylurea-Sensitive ATP-Modulated Potassium Channel.- II Functional Analysis of Ion Channels.- 4 Xenopus Oocytes as an Expression System for Ion Channels.- 5 Reconstitution of Muscle Calcium Channel Function in Bilayer Membranes: From the First Steps to Results.- 6 Approaches to Studying the Interaction between G-Proteins and Voltage-Dependent Ca2+ Channels.- 7 Influence of GABA on Potassium Channels in Hippocampal Neurons.- 8 Estimation of Drug Affinities for Calcium Channel Conformational States.- III Specific Methods and Tools.- 9 Production of Monoclonal Antibodies against Low-Abundance Ion-Channel-Associated Proteins in Neuronal Tissue.- 10 A Highly Porous Sodium Dodecyl Sulfate-Polyacrylamide Gel System: A Versatile Technique for Protein Structure and Function Study.- 11 Synthesis and Properties of Diazipine, a Novel Photoaffinity Probe for Calcium Channel-Linked Dihydropyridine Receptors.

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