Overview

Without metastasis, prostate cancer would be both tolerable and treatable. The high incidence of indolent and organ confined disease is testament to this sweeping generalisation. Equally, if molecular markers of metastatic spread can be identified, then the choice of treatment for many patients would be easier and more radical, even curative. However, should prevention and treatment of the primary tumors prove difficult or impossible, then a knowledge of the phenotype of advanced metastatic tumors should allow us to target these lesions for destruction by conventional (drug based) or more innovative means such as gene and/or immunotherapy (1). The process of metastasis has been reviewed many times (e. g. , 2) and has been subdivided for ease of analysis into a number of discrete stages (see Figure 1). It has been suggested that at least 10 separate genetic 2. ECM degradation: migration MMP ; Integrin ; TIMP 3. Intravasation MMP TIMP 1. Cellular independence 4. Transport Adhesion loss and evasion (E Cadherin ) of host immune system MHCClass1 ICAM-1 to block T cell receptor 5. Arrest of movement: endothelial adhesion CD44 or switch 6. Extravasation to colonise new site 7. Proliferation at Laminin R distant site to form Integrin switch METASTASIS Figure 1. Stages in prostate cancer metastasis. Basic processes in tumor metastases are indicated in the boxes with some key changes in gene expression indicated at each stage by the solid arrows.

Full Product Details

Author:   Richard J. Ablin ,  Malcolm D. Mason
Publisher:   Springer
Imprint:   Springer
Edition:   2007 ed.
Volume:   10
Dimensions:   Width: 15.50cm , Height: 2.20cm , Length: 23.50cm
Weight:   0.646kg
ISBN:  

9789401781527

ISBN 10:   9401781524
Pages:   407
Publication Date:   23 November 2014
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Chapter 1: Introduction: Metastasis as a Therapeutic Target Richard J. Ablin and Malcolm D. Mason Chapter 2: The Natural History of Prostate Cancer David F. Penson and Peter C. Albertsen Chapter 3: The Search for Genes Which Influence Prostate Cancer Metastasis: A Moving Target? Norman J. Maitland Chapter 4: Polyunsaturated Fatty Acids and Prostate Cancer Metastasis Wen G. Jiang Chapter 5: Role of Prostaglandin Synthesis and Cyclooxygenase-2 in Prostate Cancer and Metastasis Alaa F. Badawi Chapter 6: Cell Cycle Regulation Ruchi M. Newman and Bruce R. Zetter Chapter 7: Epithelial-Mesenchymal Molecular Interactions in Prostatic Tumor Cell Plasticity Mary J.C. Hendrix, Jun Luo, Elisabeth A. Seftor, Navesh Sharma, Paul M. Heidger Jr., Michael B. Cohen, Robert Bhatty, Jirapat Chungthapong, Richard E.B. Seftor, and David Lubaroff Chapter 8: Orthotopic Metastatic Mouse Models of Prostate Cancer Robert M. Hoffman Chapter 9: ß-Catenin, its Binding Partners and Signalling Mechanisms: Implications in Prostate Cancer Gaynor Davies, Gregory M. Harrison, and Malcolm D. Mason Chapter 10: Hepatocyte Growth Factor/Scatter Factor and Prostate Cancer Metastasis Gaynor Davies, Wen G. Jiang, and Malcolm D. Mason Chapter 11: Matrix Degradation in Prostate Cancer Michael J. Wilson and Akhouri A. Sinha Chapter 12: The Biology of Bone Metastases from Prostate Cancer and the Role of Bisphosphonates Noel W. Clarke and Herbert A. Fleisch Chapter 13: Non-Steroidal Anti-Androgen Use as Part of Combined Androgen Blockade Therapy for Metastatic or Locally Advanced Prostate Cancer: a Review of the Evidence on Efficacy and Toxicity Mike Shelley, Charles Bennett, Derek Nathan, and Oliver Sartor Chapter 14: Strategies for the Implementation of Chemotherapy and Radiotherapy Paula Scullin, Joe M. O’Sullivan, and Christopher C. Parker Chapter 15: Immuno-gene Therapy for Metastatic Prostate Cancer Takefumi Satoh, Terry L. Timme, Yehoshua Gdor, Brian J. Miles, Robert J. Amato, Dov Kadmon, and Timothy C. Thompson Chapter 16: Distilling the Past – Envisioning the Future Richard J. Ablin and Malcolm D. Mason

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