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OverviewIn this book we present a largely biochemical look at the metals of life and their functions, which we hope will be of interest to chemists and biologists as well as biochemists. The field of 'inorganic bio chemistry' is one of rapid change. Recent developments in our know ledge of the activity of calcium, and of the iron-sulphur proteins, are two examples, and increasing attention is being paid to non-metals as well [3]. For reasons of space, we shall restrict ourselves to the normal biological activities of metals. We must ignore, on the one hand, the gross physiological effects of metal deficiency or toxicity, and on the other, the many model studies which have been stimulated by the unusual properties of metals in biological systems. Usually the synthesis of model metal compounds follows rather than anticipates the dis covery of novel biological configurations. However, such studies give us a firm basis for an understanding of the biological systems, and sometimes answer questions that cannot be tackled any other way (for instance, what is the net charge on an iron-sulphur cluster?). As a result, we can refer to new and interesting information on the metals oflife at a chemical level. We gratefully acknowledge the help of Professor P. Banks and Dr D. Fenton who have read and criticized the manuscript, though any errors or misconceptions remain our own responsibility. We thank Mr P. Elliot for preparing Fig. 5.2. Full Product DetailsAuthor: P. Harrison , R. HoarePublisher: Chapman and Hall Imprint: Chapman and Hall Dimensions: Width: 14.00cm , Height: 0.40cm , Length: 21.60cm Weight: 0.122kg ISBN: 9780412131608ISBN 10: 0412131609 Pages: 80 Publication Date: 30 October 1980 Audience: College/higher education , Professional and scholarly , Undergraduate , Postgraduate, Research & Scholarly Format: Paperback Publisher's Status: Active Availability: In Print  This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of Contents1 The essential metals and their evolution.- 1.1 The major metals.- 1.2 The minor metals.- 1.3 Metals and early biochemical evolution.- 2 The non-redox roles of metals ions.- 2.1 Active sites of the non-redox metals.- metal activity, specificity and selectivity.- the alkali metals.- magnesium.- calcium.- zinc and other metals.- 2.2 Regulatory and trigger roles of metal ions.- metal ions and regulatory enzymes.- the trigger roles of calcium.- secretion from cytoplasmic granules.- activation of muscle contraction.- 3 Electron transfer and redox reactions.- 3.1 Metals as redox catalysts.- 3.2 Electron carrier proteins.- cytochromes.- the blue copper site.- iron-sulphur proteins.- 3.3 Some enzymes containing molybdenum, cobalt and iron.- molybdenum.- cobalt.- ribonucleotide reductases.- 3.4 Electron transfer in respiration and photosynthesis.- 4 Dealing with oxygen.- 4.1 The activation and toxicity of oxygen.- 4.2 Oxygen carriers.- myoglobin and haemoglobin.- haemo-cyanin.- haemerythrin.- 4.3 Superoxide dismutases.- 4.4 Oxidases.- cytochrome oxidase.- the blue oxidases.- 4.5 Oxygenases.- monoxygenases.- dioxygenases.- 4.6 Hydroperoxidases.- 4.7 Some oxygen-activating groups.- 5 Metal metabolism.- 5.1 Microbial ion carriers.- ionophores.- siderophores.- 5.2 The major metals.- translocation across membranes.- the internal fluid media of animals.- 5.3 The minor metals.- iron.- zinc.- copper.- other metals.- Suggestions for further reading.ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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