Overview

This title is not available to purchase from Royal Society of Chemistry. Please visit www.bioinorganic-chemistry.org/mils for title information.   Volume 8, solely devoted to the toxicology of metals and metalloids as well as their compounds, focuses on human health. Not surprisingly, all related research areas are rapidly developing due to the role of metals and metalloids in the environment, for the work place, for food and water supply, etc. Written by 40 internationally recognized experts, the 14 stimulating chapters provide an authoritative and timely resource for scientists working in the wide range from analytical, physical, inorganic, and environmental biochemistry all the way through to toxicology, physiology, and medicine. Volume 8 highlights, supported by nearly 1900 references, in a comprehensive and timely manner the principles of risk assessment regarding the effects of metals on human health. It examines how metal ions and their compounds affect the pulmonary, cardiovascular, gastrointestinal (including liver), hematological, immune, and neurological systems, the kidney, skin and eyes, as well as human reproduction and development. MILS-8 terminates with the role of metal ions as endocrine disrupters, in genotoxicity, and cancer risk.

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9781849730914

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Reviews

'Overall this volume provides a quick and comprehensive reference with in-depth analysis and provocative discussion of the roles of normal and aberrant metal ion and metalloid function in various aspects of human health. It is sue reo prove a valuable resource for the discipline and will help spur new research initiatives in the field'.'should be useful for students and researchers in academia and industry, risk assessors and physicians alike'. * Barry Lever * 'The volume continues the reputation for excellence established by the editors.''The volume provides a definitive and comprehensive compendium of topics with sufficiently broad detail for the understanding of a wide range of toxicological principles relevant to metal ions and metalloids.''It is sure to prove a valuable resource for the discipline and will helpspur new research initiatives in the field, It should be useful for students and researchers in academia and industry, risk assessors and physicians alike.' * Michael Aschner *

Author Information

Astrid Sigel has studied languages and was an editor of the Metal Ions in Biological Systems series (until Volume 44) and also of the Handbooks on Toxicity of Inorganic Compounds (1988), on Metals in Clinical and Analytical Chemistry (1994; both with H. G. Seiler) and on Metalloproteins (2001; with Ivano Bertini). Helmut Sigel is Emeritus Professor (2003) of Inorganic Chemistry at the University of Basel, Switzerland, and a previous editor of the MIBS series until Volume 44. He serves on various editorial and advisory boards, published over 300 articles on metal ion complexes of nucleotides, coenzymes, and other ligands of biological relevance, and lectured worldwide. He was named Protagonist in Chemistry (2002) by ICA (issue 339); among further honors are the P. Ray Award (Indian Chemical Society, of which he is also an Honorary Fellow), the Werner Award (Swiss Chemical Society), a Doctor of Science honoris causa degree (Kalyani University, India), appointments as Visiting Professor (e.g., Austria, China, Japan, UK) and Endowed Lectureships. Roland K. O. Sigel is Associate Professor (2009) of Inorganic Chemistry at the University of Z³rich, Switzerland,; from 2003 to 2008 he was endowed with a F÷rderungsprofessur of the Swiss National Science Foundation. He received his doctoral degree summa cum laude (1999) from the University of Dortmund, Germany, working with Bernhard Lippert. Thereafter he spent nearly three years at Columbia University, New York, USA, with Anna Marie Pyle (now Yale University). During the six years abroad he received several prestigeous fellowships from various sources, and he was awarded the EuroBIC Medal in 2008. His research focuses on the structural and catalytic role of metal ions in ribozymes, especially group II introns, and on related topics. He was also an editor of Volumes 43 and 44 of the MIBS series.

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