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OverviewIn this volume a comprehensive review of membrane proteins that regulate complement and perforin-mediated cytolysis is presented. A detailed analysis is provided of the biochemical, molecular, and functional features of these proteins. The glycosyl-phosphatidyl-inositol linked proteins are covered, with emphasis placed on the functional importance of this type of membrane anchor. Further chapters include reviews of the effects of complement activation on cells that are metabolically active, and of the regulation of cell killing by cytotoxic lymphocytes, considering the similarities and disparities between the complement and perforin systems. The therapeutic use of recombinant CRI for immune-mediated pathophysiological processes is discussed in a separate section. Full Product DetailsAuthor: Charles J. ParkerPublisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Imprint: Springer-Verlag Berlin and Heidelberg GmbH & Co. K Volume: v.178 Weight: 0.435kg ISBN: 9783540546535ISBN 10: 3540546537 Pages: 196 Publication Date: 11 June 1992 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: Out of stock  The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available. Table of ContentsList of Contents.- Regulation of Complement by Membrane Proteins: An Overview.- Decay Accelerating Factor (CD55).- Complement Receptor Type 1.- Membrane Cofactor Protein.- Membrane Inhibitor of Reactive Lysis.- Homologous Restriction Factor.- The Effects of Complement Activation on Platelets.- Effects of the Membrane Attack Complex of Complement on Nucleated Cells.- Glycosyl-Phosphatidylinositol Anchoring of Membrane Proteins.- Paroxysmal Nocturnal Hemoglobinuria.- Perforin-Structure, Function, and Regulation.ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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