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OverviewCovering key topics for drug discovery from the perspective of the practising industrial scientist and manager, this text presents all aspects of the subject of medicinal chemistry from initial lead through to final development. This edition builds on the successful foundations laid by the first edition by introducing new topics such as combinatorial chemistry, genomics and cheminformatics, alongside revised and updated original chapters. Introducing the cross-disciplinary topics needed, it embraces descriptions of targets, biology, metabolism and pharmacokinetics, genetics, patents and development chemistry. New case histories, strategy and tactics for drug discovery are also introduced. With many chapters written by practitioners from within the pharmaceutical industry, the text serves as a useful introduction to medicinal chemistry for new graduates and PhDs. It also serves to update more experienced scientists on the newer technologies in the field. Full Product DetailsAuthor: Frank D King , Steve Bromidge , Paul Smith , R J SlaterPublisher: Royal Society of Chemistry Imprint: Royal Society of Chemistry Edition: 2nd edition Dimensions: Width: 15.60cm , Height: 2.50cm , Length: 23.40cm Weight: 1.467kg ISBN: 9780854046317ISBN 10: 0854046313 Pages: 472 Publication Date: 30 September 2002 Audience: College/higher education , Professional and scholarly , Undergraduate , Postgraduate, Research & Scholarly Format: Paperback Publisher's Status: Active Availability: In Print  This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of ContentsAn Introduction to Drug-Receptor Interactions; Signal Transduction and Second Messengers; Enzyme Inhibitors; The Biological Evaluation of New Compounds; Pharmacokinetics; Drug Metabolism; Physicochemical Properties and Drug Design; Quantitative Structure-Activity Relationships; Considerations for the Use of Computational Chemistry Techniques by Medicinal Chemists; `Patent Medicine'; Molecular Biology - A New Route to Drug Discovery; Devising a Research Strategy; Past Approaches to Discovering New Drugs as Medicines; Bioisosteres, Conformational Restriction, and Pro-drugs: Approaches to Lead Optimisation - Case History: An Example of a Conformational Restriction Approach; The Design and Synthesis of Selective Protein Kinase C Inhibitors; Discovery of 1069C - A Novel Synthetic Antitumour Agent with Low Cross-resistance Potential; The Design and Biological Properties of `Dipeptoid' Antagonists; Migraine Therapy - From Serotonin to Sumatriptan; Drug Development; Appendices; Subject Index.Reviews... an excellent book with many useful insights for the medicinal chemist engaged in drug discovery/development. -- Journal of Medicinal Chemistry, 2003, Vol 46, No 9, p 1773-1774 Journal of Medicinal Chemistry ... an excellent introduction into the field and to the role of medicinal chemistry in drug discovery ... a valuable addition to institutional libraries and to the personal libraries of graduate students and new practitioners of medicinal chemistry, particularly those in an industrial setting. -- Journal of the American Chemical Society, Vol 125, No 22, 2003 Journal of the American Chemical Society ... valuable not only for medicinal or chemistry workers, but is also suitable for graduate students and scientists working in the pharmaceutical and medical area, providing up to date information on newer technologies. -- Carbohydrate Polymers, 55, 2004, 115 Carbohydrate Polymers An essential text...presentation is clear and the text written in an understandable, readable style. -- Chemistry & Industry, 16 August 2004 (Gareth Thomas) Chemistry and Industry Author InformationTab Content 6Author Website:Countries AvailableAll regions |
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