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Author:   Norma K Dunlap (Middle Tennessee State University, USA) ,  Donna M Huryn (University of Pennsylvania and University of Pittsburgh, USA)
Publisher:   Taylor & Francis Ltd
Imprint:   CRC Press
Edition:   2nd edition
Weight:   1.050kg
ISBN:  

9781032737164

ISBN 10:   1032737166
Pages:   466
Publication Date:   09 December 2025
Audience:   College/higher education ,  Professional and scholarly ,  Tertiary & Higher Education ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Not yet available  
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Table of Contents

PART I: DRUG DISCOVERY AND DEVELOPMENT Chapter 1: Historical Perspective and Overview of Drug Discovery Chapter 2: Drug Discovery: Hit and Lead Identification Chapter 3: Lead Optimization: Drug-Target Interactions and the Pharmacophore Chapter 4: Lead Optimization: Properties Optimized and Medicinal Chemistry Strategies Chapter 5: The Process of Developing a Drug from an Optimized Lead PART II: CLASSES OF DRUG TARGETS Chapter 6: Receptors, Ion Channels, and Transporters as Drug Targets Chapter 7: Enzymes as Drug Targets Chapter 8: Protein–Protein and Lipid Structure Interactions as Drug Targets Chapter 9: DNA and RNA as Drug Targets PART III: SELECTED THERAPEUTIC AREAS Chapter 10: Anti-Cancer Drugs Chapter 11: Antiviral and Antifungal Agents Chapter 12: Antibacterial and Antiparasitic Drugs Chapter 13: Drugs Acting on the Central Nervous System

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Author Information

Norma Dunlap is Professor Emerita of Chemistry at Middle Tennessee State University, where she specialized in synthetic organic chemistry and medicinal chemistry. Her research, done primarily with undergraduates and M.S. students, was focused on design and synthesis of bioactive peptidomimetics. She holds a Ph.D. in organic chemistry from the University of Wyoming and was an NIH postdoctoral fellow at the University of Pennsylvania. She began her career as a Senior Research Scientist at Hoffmann-La Roche, in drug discovery. After moving to academia, she was a Lecturer at Vanderbilt University before moving to Middle Tennessee State University. Donna M. Huryn is Professor of Practice in the Chemistry Department at the University of Pennsylvania where her research focuses on medicinal chemistry projects on novel drugs to treat kidney disease, cancer and rare genetic diseases. She holds a Ph.D. from the University of Pennsylvania. She started her career in industry at Hoffmann-LaRoche and then Wyeth Research before joining academia; she was previously a faculty member at the University of Pittsburgh School of Pharmacy. She is a Fellow of the American Association for the Advancement of Science and the American Chemical Society and was inducted into the ACS Division of Medicinal Chemistry Hall of Fame. She is recipient of the ACS Philadelphia Local Section Award, the Philip S. Portoghese Lectureship, and the Garvin-Olin Medal. From 2014-2023 was Associate Editor of ACS Medicinal Chemistry Letters. In 2019, she co-founded Empowering Women in Organic Chemistry (EWOC), and continues to serve on the organizing committee.

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