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OverviewIn response to a plethora of genotoxic reactions, all forms of life ranging from bacteria to man, possess multiple systems for either repairing damage inflicted on DNA or, alternatively, increasing their tolerance to it. This book summarizes existing knowledge on how these DNA damage processing pathways are selectively targeted to defective sites in the mammalian genome. It discusses the biological, clinical and toxicological implications of DNA damage recognition in a comprehensive manner. For example, DNA adducts formed by the anticancer drug Cisplatin are recognized by excision repair factors, transcription factors, DNA polymerases, RNA polymerases or recombination factors. The consequences of each of these molecular recognition functions are discussed in detail. Full Product DetailsAuthor: Hanspeter NaegeliPublisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Imprint: Springer-Verlag Berlin and Heidelberg GmbH & Co. K ISBN: 9783540627159ISBN 10: 3540627154 Pages: 222 Publication Date: 01 May 1997 Audience: College/higher education , Professional and scholarly , Postgraduate, Research & Scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: Out of stock  The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available. Table of ContentsReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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