Overview

Whole new areas of immunological research are emerging from the analysis of experimental data, going beyond statistics and parameter estimation into what an applied mathematician would recognise as modelling of dynamical systems. Stochastic methods are increasingly important, because stochastic models are closer to the Brownian reality of the cellular and sub-cellular world.

Full Product Details

Author:   Carmen Molina-París ,  Grant Lythe
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   2011 ed.
Dimensions:   Width: 15.50cm , Height: 2.80cm , Length: 23.50cm
Weight:   0.799kg
ISBN:  

9781441977243

ISBN 10:   1441977244
Pages:   407
Publication Date:   06 May 2011
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Preface.- Thymocyte development.- A review of mathematical models for T cell receptor triggering and antigen discrimination.- Dynamic tuning of T cell receptor specificity by co-receptors and costimulation.- T cell activation and function: role of signal strength.- The cyton model for lymphocyte proliferation and differentiation.- Modeling itravital two-photon data of lymphocyte migration and interaction.- Modeling lymphocyte dynamics in vivo.- Continuous-time birth and death processes: diversity maintenance of naïve T cells in the periphery.- Multivariate competition processes: a model for two competing T cell clonotypes.- Stochastic modeling of T Cell homeostasis for two competing clonotypes via the master equation.- Dendritic cell migration in the intestinal tract.- Reassessing germinal center reaction concepts.- B cell strategies of Ag recognition in a stratified immune system.- Dynamics of Peripheral regulatory and effector T cells competing for antigen presenting cells.- Mathematical models of the role of IL-2 in the interactions between helper and regulstory CD4+ T cells.- A Physicist’s approach to immunology.- Timescales of the adaptive immune response.- Using mathematical models to explore the role of cytoxic T lymphocytes in HIV infection.- Viral immunity and persistence.- Index.

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