Mass Spectrometry of Nucleosides and Nucleic Acids

Author:   Joseph H. Banoub ,  Patrick A. Limbach
Publisher:   Taylor & Francis Ltd
ISBN:  

9780367384685


Pages:   504
Publication Date:   23 September 2019
Format:   Paperback
Availability:   In Print   Availability explained
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Mass Spectrometry of Nucleosides and Nucleic Acids


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Author:   Joseph H. Banoub ,  Patrick A. Limbach
Publisher:   Taylor & Francis Ltd
Imprint:   CRC Press
Weight:   0.929kg
ISBN:  

9780367384685


ISBN 10:   036738468
Pages:   504
Publication Date:   23 September 2019
Audience:   College/higher education ,  Professional and scholarly ,  Tertiary & Higher Education ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print   Availability explained
This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us.

Table of Contents

Overview of Recent Developments in the Mass Spectrometry of Nucleic Acid and Constituents. Mass Spectrometric Analysis of Deoxyinosines. Tandem Mass Spectrometry of Nucleic Acids. Mass Spectrometric Application in the Study of Cyclic Nucleotides in Biochemical Signal Transduction. Analysis of Urinary Modified Nucleosides by Mass Spectrometry. Mass Spectrometric Determination of DNA Adducts in Human Carcinogenesis. Sequence Distribution of Nucleobase Adducts Studied by Isotope Labeling of DNA-Mass Spectrometry. Electrospray Mass Spectrometry of Noncovalent Complexes between Small Molecule Ligands and Nucleic Acids. Electrospray Ionization-Mass Spectrometry for the Investigation of Protein–Nucleic Acid Interactions. Characterization of Noncovalent Complexes of Nucleic Acids with Peptides and Proteins by Mass Spectrometry. MALDI-TOF Detection of Specific Noncovalent Complexes of Highly Acidic Biomolecules with Pyrenemethylguanidinium. Quantitative Identifi cation of Nucleic Acids via Signature Digestion Products Detected Using Mass Spectrometry. Electrospray Ionization Mass Spectrometry for the Direct Analysis of Modified Nucleosides in Small RNAs. LC-MS/MS for the Examination of the Cytotoxic and Mutagenic Properties of DNA Lesions. Influence of Metal Ions on the Structure and Reactivity of Nucleic Acids. Index.

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Author Information

Joseph H. Banoub is a principal scientist and head of the special projects at Fisheries and Oceans Canada, Science Branch. He has been an adjunct professor of biochemistry at Memorial University of Newfoundland since 1984 and an adjunct professor of chemistry since 2006. His present research interests include the uses of tandem mass spectrometry for the structural elucidation of biologically active molecules. Patrick A. Limbach is a professor of chemistry and department head at the University of Cincinnati. His research interests include the development of new mass spectrometry methods for analyzing RNAs, the identification of unknown modified nucleosides, the characterization of RNA–protein complexes, and investigating the role of modified nucleosides in biological systems.

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