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OverviewThis book provides a comprehensive description of sterols and their novel biological roles in mammalian signaling, the book covers their biosynthesis and structure, describes sterol receptor -mediated actions, their tissue distribution and their role in disease. It offers insight into new research findings, focusing specifically on novel discoveries in bile acid and oxysterol signaling, including the lanosterol-to-cholesterol intermediates. Special attention is paid on the sex distribution of these sterols (male or female) and their sexually dimorphic roles in mammalian species, such as human, rat and mouse. Since sterols and drugs (xenobiotics) use many identical receptor-mediated signaling pathways, the book will be interesting for researchers working on the cross-road of endogenous and xenobiotic metabolism, it is intended for advanced students and scientists in molecular biology and biochemistry as well as for medical doctors in hepatology. Full Product DetailsAuthor: Damjana Rozman , Rolf GebhardtPublisher: Springer Nature Switzerland AG Imprint: Springer Nature Switzerland AG Edition: 1st ed. 2020 Weight: 0.342kg ISBN: 9783030396862ISBN 10: 303039686 Pages: 171 Publication Date: 12 August 2021 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of ContentsSterols from the post-lanosterol part of cholesterol synthesis – novel signaling players.- Genetic variability in cholesterol metabolism.- Side-chain oxidized oxysterols in health and disease.- Bile acids and TGR5 (Gpbar1) signaling.- Bile acids as regulatory signalling molecules.- Oxysterols and bile acid act as signaling molecules that regulate cholesterol homeostasis: nuclear receptors LXR, FXR, and fibroblast growth factor 15/19.- Cytochrome P450 Metabolism Leads to Novel Biological Sterols and Other Steroids.ReviewsAuthor InformationDamjana Rozman is full Professor of Biochemistry and Molecular Biology at the Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Slovenia and Head of the Centre for Functional Genomcis and Bio-Chips (CFGBC). Rolf Gebhardt is Professor (em.) of Biochemistry at the Rudolf Schönheimer Institute of Biochemistry, Department of General Biochemistry, University of Leipzig, Faculty of Medicine, Leipzig, Germany. Tab Content 6Author Website:Countries AvailableAll regions |
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