Overview

The result of a meeting held at IARC early in 1996, this volume provides a thorough and up-to-date synthesis of the mechanisms of fibre carcinogenesis. A consensus document assesses the strengths, weaknesses and gaps in the data concerning fibre characterization and genotoxicity, fibre-related cell proliferation and activation, gene expression, animal models, mixed dust exposures and interactions with other carcinogens. The relevance of mechanistic data from in vitro and in vivo assays to the evaluation of fibre carcinogenicity are also discussed. Authored review papers, also published in this volume, provide the background material for much of the discussion.

Full Product Details

Author:   A.B. Kane ,  etc. ,  P. Boffeta ,  R. Saracci (Doctor, International Agency for Research on Cancer, Lyon, France)
Publisher:   International Agency for Research on Cancer
Imprint:   International Agency for Research on Cancer
Volume:   No.140
Dimensions:   Width: 17.00cm , Height: 1.30cm , Length: 24.00cm
Weight:   0.317kg
ISBN:  

9789283221401

ISBN 10:   9283221400
Pages:   170
Publication Date:   27 February 1997
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

1. Consensus report; 2. Mechanisms of mineral fibre carcinogenesis; 3. Use of physico-chemical and cell-free assays to evaluate the potential carcinogenicity of fibres; 4. Use of in-vitro genotoxicity and cell transformation assays to evaluate the potential carcinogenicity of fibres; 5. Effects of fibres on cell proliferation, cell activation and gene expression; 6. Short-term animal studies for detecting inflammation, fibrosis and pre-neoplastic changes induced by fibres; 7. Evaluation and use of animal models to assess mechanisms of fibre carcinogenicity; 8. Mixed fibrous and non-fibrous dust exposures and interactions between agents in fibre carcinogenesis

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