Overview

This volume examines each known cathepsin in turn, examining gene structure and localization; precursors, purification, activation and inhibition; and hydrolysis of synthetic substrates, polypeptides and proteins.

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9780198502494

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Reviews

"""...this is a powerful book which shows clearly that research on proteases is a fast-moving field and which should be essential for all scientists attempting to keep up with any aspect of proteolysis"" Cell Biology International"

<br> This book would be a worthwhile addition to the library of anyone with an interest in lysosomal proteinases.--Doody's Journal<br> This book is part of a series that provides comprehensive data on the structure, kinetics and biochemistry of individual families of proteins. The current book focuses on the major family of mammalian lysosomal cysteine proteinases that are related by sequence and structure to papain. Biochemical details of cathepsins B, H, K, L, and S and dipeptidyl peptidase are clearly presented. An unrelated lysosomal cysteine proteinase, legumain, is also discussed briefly. The structural section gives useful lists of important amino acids that play significant roles in both the structure and catalytic specificity of the enzymes. . . . [A] succinct, readable review of the lysosomal cysteine proteinases. The bibliography occupies more than half of the book, and lists 1830 references that cover all areas of research on mammalian lysosomal cysteine proteinases, making

This book would be a worthwhile addition to the library of anyone with an interest in lysosomal proteinases.--Doody's Journal<br> This book is part of a series that provides comprehensive data on the structure, kinetics and biochemistry of individual families of proteins. The current book focuses on the major family of mammalian lysosomal cysteine proteinases that are related by sequence and structure to papain. Biochemical details of cathepsins B, H, K, L, and S and dipeptidyl peptidase are clearly presented. An unrelated lysosomal cysteine proteinase, legumain, is also discussed briefly. The structural section gives useful lists of important amino acids that play significant roles in both the structure and catalytic specificity of the enzymes. . . . [A] succinct, readable review of the lysosomal cysteine proteinases. The bibliography occupies more than half of the book, and lists 1830 references that cover all areas of research on mammalian lysosomal cysteine proteinases, making this book a valuable resource for those who wish to get up to date on this group of enzymes. --The Quarterly Review of Biology<br> This book, which is part of a series on protein profiles, focuses on lysosomal cysteine proteinases. The book contains tables and figures listing key information gathered from the literature with comprehensive reference to primary sources. This book provides a practical, comprehensive and accessible information source on lysosomal cysteine proteinases to anyone interested in the topic. -- Biosis, Vol 51, Issue 4, April 22, 1999<br>

This book would be a worthwhile addition to the library of anyone with an interest in lysosomal proteinases.--Doody's Journal This book is part of a series that provides comprehensive data on the structure, kinetics and biochemistry of individual families of proteins. The current book focuses on the major family of mammalian lysosomal cysteine proteinases that are related by sequence and structure to papain. Biochemical details of cathepsins B, H, K, L, and S and dipeptidyl peptidase are clearly presented. An unrelated lysosomal cysteine proteinase, legumain, is also discussed briefly. The structural section gives useful lists of important amino acids that play significant roles in both the structure and catalytic specificity of the enzymes. . . . [A] succinct, readable review of the lysosomal cysteine proteinases. The bibliography occupies more than half of the book, and lists 1830 references that cover all areas of research on mammalian lysosomal cysteine proteinases, making this book a valuable resource for those who wish to get up to date on this group of enzymes. --The Quarterly Review of Biology This book, which is part of a series on protein profiles, focuses on lysosomal cysteine proteinases. The book contains tables and figures listing key information gathered from the literature with comprehensive reference to primary sources. This book provides a practical, comprehensive and accessible information source on lysosomal cysteine proteinases to anyone interested in the topic. -- Biosis, Vol 51, Issue 4, April 22, 1999

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