Overview

Efforts to describe and model the molecular structure of biological membranes go back to the beginning of the last century. In 1917, Langmuir described membranes as a layer of lipids one molecule thick [1]. Eight years later, Gorter and Grendel concluded from their studies that “the phospholipid molecules that formed the cell membrane were arranged in two layers to form a lipid bilayer” [2]. Danielli and Robertson proposed, in 1935, a model in which the bilayer of lipids is sequestered between two monolayers of unfolded proteins [3], and the currently still accepted fuid mosaic model was proposed by Singer and Nicolson in 1972 [4]. Among those landmarks of biomembrane history, a serendipitous observation made by Alex Bangham during the early 1960s deserves undoubtedly a special place. His fnding that exposure of dry phospholipids to an excess of water gives rise to lamellar structures [5] has opened versatile experimental access to studying the biophysics and biochemistry of biological phospholipid membranes. Although during the following 4 decades biological membrane models have grown in complexity and functionality [6], liposomes are, besides supported bilayers, membrane nanodiscs, and hybrid membranes, still an indisputably important tool for membrane b- physicists and biochemists. In vol. II of this book, the reader will fnd detailed methods for the use of liposomes in studying a variety of biochemical and biophysical membrane phenomena concomitant with chapters describing a great palette of state-of-the-art analytical technologies.

Full Product Details

Author:   Volkmar Weissig
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   Softcover reprint of the original 1st ed. 2010
Volume:   605
Weight:   1.474kg
ISBN:  

9781493957088

ISBN 10:   1493957082
Pages:   564
Publication Date:   23 August 2016
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Current Trends in Liposome Research.- Nanoliposomes: Preparation and Analysis.- Preparation of DRV Liposomes.- Elastic Liposomes for Topical and Transdermal Drug Delivery.- Archaebacterial Tetraetherlipid Liposomes.- Cationic Magnetoliposomes.- Ultrasound-Responsive Liposomes.- Liposome Formulations of Hydrophobic Drugs.- Remote Loading of Anthracyclines into Liposomes.- Arsonoliposomes: Preparation and Physicochemical Characterization.- Liposome-Based Vaccines.- Mannosylated Liposomes for Targeted Vaccines Delivery.- Liposomes for Specific Depletion of Macrophages from Organs and Tissues.- Vesicular Phospholipid Gels.- Environment-Responsive Multifunctional Liposomes.- Functional Liposomal Membranes for Triggered Release.- A “Dock and Lock” Approach to Preparation of Targeted Liposomes.- Conjugation of Ligands to the Surface of Preformed Liposomes by Click Chemistry.- Targeted Magnetic Liposomes Loaded with Doxorubicin.- Liposomes for Drug Delivery to Mitochondria.- Cytoskeletal-Antigen Specific Immunoliposomes: Preservation of Myocardial Viability.- Gadolinium-Loaded Polychelating Polymer-Containing Tumor-Targeted Liposomes.- Angiogenic Vessel-Targeting DDS by Liposomalized Oligopeptides.- TAT-Peptide Modified Liposomes: Preparation, Characterization, and Cellular Interaction.- ATP-Loaded Liposomes for Targeted Treatment in Models of Myocardial Ischemia.- Intracellular ATP Delivery Using Highly Fusogenic Liposomes.- Lipoplex Formation Using Liposomes Prepared by Ethanol Injection.- Acid-Labile Liposome/pDNA Complexes.- Serum-Resistant Lipoplexes in the Presence of Asialofetuin.- Anionic pH Sensitive Lipoplexes.- Liposomal siRNA Delivery.- Complexation of siRNA and pDNA with Cationic Liposomes: The Important Aspects in Lipoplex Preparation.- Effective In Vitro andIn Vivo Gene Delivery by the Combination of Liposomal Bubbles (Bubble Liposomes) and Ultrasound Exposure.- Liposomal Magnetofection.- Long-Circulating, pH-Sensitive Liposomes.- Serum-Stable, Long-Circulating, pH-Sensitive PEGylated Liposomes.

Reviews

From the reviews: The book provides in-depth descriptions of tumor and gene therapies, focusing on cationic liposomes. ... The book presents the most seminal studies on the application of liposomes in the pharmaceutical area published over the past two decades. ... the content provides the reader with a comprehensive overview of the topic and constitutes essential reading for those working or intending to work in the development of drug nanocarriers. (Nadia Araci Bou Chacra, Brazilian Journal of Pharmaceutical Sciences, Vol. 46 (4), October-December, 2010) Provide a comprehensive guide to the preparation, characterisation, and potential use of currently known types of liposomes. They are written using an interdisciplinary approach, and so provide essential knowledge of liposomes, for not only researchers in this particular field, but also scientists in wider pharmaceutical and biological areas. ... very inspiring - the potential for liposomes is immense - and these well-written chapters ignited notions of further applications - this is clearly a very exciting field. (Trudy L. Knight, BTS Newsletter, Issue 37, Winter, 2010)

From the reviews: “The book provides in-depth descriptions of tumor and gene therapies, focusing on cationic liposomes. … The book presents the most seminal studies on the application of liposomes in the pharmaceutical area published over the past two decades. … the content provides the reader with a comprehensive overview of the topic and constitutes essential reading for those working or intending to work in the development of drug nanocarriers.” (Nádia Araci Bou Chacra, Brazilian Journal of Pharmaceutical Sciences, Vol. 46 (4), October-December, 2010) “Provide a comprehensive guide to the preparation, characterisation, and potential use of currently known types of liposomes. They are written using an interdisciplinary approach, and so provide essential knowledge of liposomes, for not only researchers in this particular field, but also scientists in wider pharmaceutical and biological areas. … very inspiring – the potential for liposomes is immense – and these well-written chapters ignited notions of further applications – this is clearly a very exciting field.” (Trudy L. Knight, BTS Newsletter, Issue 37, Winter, 2010)

Author Information

Tab Content 6

Author Website:  

Customer Reviews

Recent Reviews

No review item found!

Add your own review!

Countries Available

All regions