Overview

This book provides a detailed and insightful exploration of liposomal drug delivery systems, a rapidly evolving technology in modern pharmaceutics. Designed for pharmacy students, formulation scientists, researchers, and regulatory professionals, the book addresses both theoretical principles and practical applications, bridging academic learning with industrial practice. Starting with an introduction to liposomal drug delivery, the book explores the design, structure, and functional role of liposomes in enhancing the therapeutic profile of drugs. Readers are guided through the selection of excipients, formulation strategies, and the manufacturing processes involved, ranging from laboratory-scale development to commercial-scale production. Key chapters focus on methods of drug loading, analytical characterization, and Quality by Design (QbD)-based formulation approaches. The book also covers targeted and long-acting liposomal systems, highlighting their significance in achieving site-specific delivery and prolonged drug action, particularly for cancer, infectious diseases, and inflammatory disorders. The text further explores real-world challenges in sterilization, stability studies, and shelf-life determination, which are critical for regulatory approval and product success. Discussions on pharmacokinetics and pharmacodynamics (PK/PD) offer insights into how liposomal carriers influence drug absorption, distribution, and therapeutic outcomes. The final chapter provides a concise overview of regulatory guidelines and compliance requirements, preparing readers for the translational journey from lab innovation to market-ready liposomal products. Comprehensive and current, this book is a valuable reference for anyone engaged in drug delivery research, formulation development, or regulatory affairs seeking to advance in the field of nanomedicine and lipid-based drug carriers.

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9781966695103

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