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Overview"Revision with unchanged content. Group I metabotropic glutamate receptors (mGluRs) play an important role in the treatment of numerous neurodegenerative, cognitive and psychiatric dis-orders. How can we identify exogenous ligands mediating the effects of mGluRs? How do these ligands affect the receptor? The author Tobias Noeske presents the establishment of strategies for the identification and optimization of molecules acting as non-competitive anta-gonists of group I mGluRs. These strategies ensure high diversity in the identi-fied chemotypes not resembling original reference molecules (""scaffold-hop-ping""). The detection of new scaffolds, in turn, is divided into two ap-proa-ches: First the development of pharmacological assays to screen com-pounds at a certain target for their bioactivity, and second the evaluation of com-pu-ter aided methods for the identification of virtual hits to be screened on the pharmacological assays. Promising molecules were optimized regarding bio-activity and selectivity, their binding mode investigated and, fi-nally, com-pared to existing lead compounds. This book addresses scientists in academia and industry working in early stage drug discovery, predominantly in computer aided drug design." Full Product DetailsAuthor: Tobias NoeskePublisher: AV Akademikerverlag Imprint: AV Akademikerverlag Dimensions: Width: 15.20cm , Height: 1.20cm , Length: 22.90cm Weight: 0.304kg ISBN: 9783639414929ISBN 10: 3639414926 Pages: 204 Publication Date: 22 May 2012 Audience: General/trade , General Format: Paperback Publisher's Status: Active Availability: In stock We have confirmation that this item is in stock with the supplier. It will be ordered in for you and dispatched immediately. Table of ContentsReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |