Overview

​This book looks at aging through research on Drosophila, the fruit fly that is one of the most widely used model organisms in bio gerontology. Work in model organisms can expand the theoretical knowledge of aging: it yields valuable insight into the molecular and cellular processes that underlie aging process, and it can perhaps provide new therapeutic targets for the treatment of age-related disorders in humans.Drosophila models have been developed for a large variety of aging-related processes and diseases, and this book provides readers with an overview of current research on the use of the Drosophila model to understand the genetic, molecular and physiological mechanisms that underlie the aging process. Themes of health span, life extension and longevity-associated genes emerge in this collation of international research on Drosophila that is of relevance to geriatrics and gerontology, animal genetics and genomics, and biomedicine. This fascinating, illustrated book will be of interest to a wide audience, ranging from academic researchers to the general reader.

Full Product Details

Author:   Alexander M. Vaiserman ,  Alexey A. Moskalev ,  Elena G. Pasyukova
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   2015 ed.
Volume:   3
Dimensions:   Width: 15.50cm , Height: 2.10cm , Length: 23.50cm
Weight:   7.342kg
ISBN:  

9783319183251

ISBN 10:   3319183257
Pages:   353
Publication Date:   25 June 2015
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Preface Alexander M. Vaiserman, Alexey A. Moskalev, Elena G. Pasyukova SECTION I: Genetic Regulation of Longevity CHAPTER 1. Neuronal Genes and Developmental Neuronal Pathways in Drosophila Lifespan Control Elena Pasyukova, Alexander Symonenko, Natalia Roshina, Mikhail Trostnikov, Ekaterina Veselkina, Olga Rybina CHAPTER 2. Gadd45 Proteins in Aging and Longevity of Mammals and Drosophila Alexey A. Moskalev, Ekaterina N. Plyusnina and Mikhail V. Shaposhnikov CHAPTER 3. Superoxide Dismutase (SOD) Genes and Aging in Drosophila John Tower CHAPTER 4. Effect of Wolbachia Infection on Aging and Longevity-Associated Genes in Drosophila Oleksandr M. Maistrenko, Svitlana V. Serga, Alexander M. Vaiserman and Iryna A. Kozeretska  SECTION II: Drosophila Models for Aging-Associated Diseases CHAPTER 5. Skeletal muscle homeostasis and aging in Drosophila Melissa J. Puppa and Fabio Demontis CHAPTER 6. Drosophila Models of Cardiac Aging and Disease Alyson Sujkowski, Chelsea Richardson and Robert Wessells CHAPTER 7. Parallels between Mammals and Flies in Inflammatory Bowel Disease Theodoulakis Christofi and Yiorgos Apidianakis CHAPTER 8. Protein Quality Control in Brain Aging: Lessons from Protein Misfolding Disorders in Drosophila Lorena de Mena, Pedro Fernandez-Funez and Diego E. Rincon-Limas CHAPTER 9. Drosophila Models in Therapeutic Drug Discovery Related to Aging Charles Nichols SECTION III: Life-Extending Treatments CHAPTER 10. Life-Extending Effect of Phytochemicals in Drosophila Lee Shin-Hae and Min Kyung-Jin CHAPTER 11. Life Extension in Drosophila by Histone Deacetylase Inhibitors Alexander M. Vaiserman and Elena G. Pasyukova CHAPTER 12. An Evolutionary Analysis of Healthspan Extension Using Diet: Have We Come to the End of the Ponce de Leon Trail? Grant A. Rutledge and Michael R. Rose CHAPTER 13. Atmosphere, Metabolism and Longevity Khatchik Muradian CHAPTER 14. Effects of Mild Stresses Applied in Adults on Aging and Longevity Éric Le Bourg CHAPTER 15. Strategies for Stage-Specific Extension of Longevity Robert Arking Index

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