Overview

Written by known specialists in the field, this is a comprehensive and timely overview of a central and expanding topic. Simultaneously an introduction and a description of the latest concepts, findings and methods, the handbook provides basic knowledge on technical issues required for those intending to research in the field. It covers the functional role of involved molecules and the cellular mechanisms, and addresses selected examples for their possible application in therapy - bridging the gap between trafficking mechanisms and novel therapeutic strategies. In addition, it includes selection of proven and timesaving methods for studying cell trafficking in vitro and in vivo. The accompanying CD-ROM makes leukocyte migration videos available to a broad audience for the first time.

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9783527312283

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Reviews

...a thorough review of the current state of knowledge in leukocyte trafficking and should be considered an important resource by scientists in related fields of research. (The Quarterly Review of Biology, December 2006) ...highly recommended for students of inflammation and leukocytes, as well as investigator of host-parasite interaction. It provides a wealth of information in this rapidly evolving field. (Microbe, July 2006)

Author Information

Professor Alf Hamann is leader of the liaison group Experimental Rheumatology located at the German Arthritis Research Centre and the Charite Hospital in Berlin. He established the research group in 1998 with a focus on basic and pathophysiological aspects of lymphocyte trafficking and immunoregulation. Professor Britta Engelhardt started her career as research group leader at the Max-Planck Institute of Vascular Cell Biology in Munster, Germany, studying the molecular mechanisms of leukocyte migration into the central nervous system. Since 2003 shehas been director of the renowned Theodor-Kocher-Institute at the University of Bern, Switzerland.

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