Overview

This book introduces readers to the biology of leukemia stem cells (LSCs) and emphasizes the necessity and importance of targeting LSCs in the treatment of hematopoietic malignancies. It addresses the role of leukemia stem cells in different leukemia diseases and molecular signatures, as well as the metabolic and epigenetic regulation of leukemia stem cell function. With regard to solid tumors, a significant number of blood cancers are believed to be derived from leukemia stem cells (LSCs), which are responsible for disease progression, relapse and drug resistance. Consequently, new therapeutic strategies need to be developed by focusing on the complete eradication of LSCs. Given its scope, the book offers a valuable asset for graduate students and scientists in the fields of cell biology and cancer research etc.

Full Product Details

Author:   Haojian Zhang ,  Shaoguang Li
Publisher:   Springer Verlag, Singapore
Imprint:   Springer Verlag, Singapore
Edition:   1st ed. 2019
Volume:   1143
Weight:   0.454kg
ISBN:  

9789811373442

ISBN 10:   9811373442
Pages:   229
Publication Date:   14 August 2020
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

Role of leukemia stem cells in pathogenesis of hematologic malignancies.- Leukemia stem cells in chronic myeloid leukemia.- Leukmeia stem cells in MLL-rearranged acute myeloid leukemia.- Interaction between leukmeia stem cells and bone marrow environment.- Molecular signatures of leukemia stem cells.- Metabolic regulation of leukemia stem cell function.- Epigenetic regulation of leukmeia stem cell function.- DNA instability and leukemia stem cell function.- Tumor suppressor genes in leukemia stem cells.- Targeting leukemia stem cells.- Leukemia stem cells and drug resistance.- Hypoxia and leukemia.

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Dr. Haojian ZhangDr. Shaoguang Li

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