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OverviewThe existence of a unique kind of immune cell – the killer lymphocyt- which destroys other cells in a highly specific manner, has fascinated immunologists for almost half a century. How do these cells, whose precursors have lived in communal harmony with their host, decide that some of their cohabitants must die? And how do they kill them? The definition of killer lymphocytes came from discovery of their roles in a wide range of in vivo phenomena such as transplant rejection, virus infection and its related immunopathologies, and anti-tumor responses. Yet for the most part almost everything we know about these cells has come from studying them in vitro. They have yielded their secrets slowly and reluctantly. To understand fully how they work, geneticists and immunologists had to unravel the major histocompatibility systems of vertebrates, a long and torturous road that provided some of the darkest hours of immunology. The search for antigen-sensing receptors on both T cells and NK cells was scarcely less frustrating. And the holy grail of ce- mediated cytotoxicity – defining the mechanism by which killer cells take down their adversaries – sorely tested the ingenuity, patience and mutual good will of laboratories around the world. These questions have now largely been answered. But do we really understand these cells? We can tame them to a large degree in transplant rejection. It may yet turn out that we can harness their immunotherapeutic potential in treating viral and malignant disease. Full Product DetailsAuthor: Gideon Berke , William R. ClarkPublisher: Springer-Verlag New York Inc. Imprint: Springer-Verlag New York Inc. Edition: 1st ed. 2005. 2nd printing 2007 Dimensions: Width: 15.50cm , Height: 1.90cm , Length: 23.50cm Weight: 1.150kg ISBN: 9781402065637ISBN 10: 1402065639 Pages: 361 Publication Date: 20 September 2007 Audience: College/higher education , Professional and scholarly , Undergraduate , Postgraduate, Research & Scholarly Format: Paperback Publisher's Status: Active Availability: In Print  This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of ContentsBasic Immunobiology: A Primer.- Cytotoxic T Lymphocytes: Generation and Cellular Properties.- Cytotoxic T Lymphocytes: Target Cell Recognition and Binding.- Cytotoxic T Lymphocytes: Target Cell Killing: Cellular Parameters.- Cytotoxic T Lymphocytes: Target Cell Killing: Molecular mechanisms.- Innate Cell-mediated Immunity.- The Role of Cytotoxicity in Allograft Rejection In Vivo.- Cytotoxicity in Immune Defenses Against Intracellular Parasites.- Killer Cells and Cancer.- Autoimmunity.- Homeostasis, Memory and CTL Vaccines.ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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