|
![]() |
|||
|
||||
OverviewKCNQ2 and KCNQ3 encode subunits (KV7.2, KV7.3) that combine to form a voltage-gated potassium ion (K+) channel responsible for generating an ionic current (M-current) important for controlling activity in the nervous system. Pathogenic variants in both genes are associated with a spectrum of genetic neurological disorders that feature epilepsy of variable severity and can be accompanied by debilitating impaired neurodevelopment. These two genes were among the first discovered causes of monogenic epilepsy, and are frequently identified in persons with early-life epilepsy. This Element provides a comprehensive review of the clinical features, genetic basis, pathophysiology, pharmacology and treatment of these prototypical neurological disorders accompanied by perspectives shared by affected families and scientists who have made seminal contributions to the field. This title is also available as Open Access on Cambridge Core. Full Product DetailsAuthor: Sarah Weckhuysen , Alfred L. George, JrPublisher: Cambridge University Press Imprint: Cambridge University Press Dimensions: Width: 15.20cm , Height: 0.70cm , Length: 22.80cm Weight: 0.180kg ISBN: 9781009278263ISBN 10: 1009278266 Pages: 75 Publication Date: 01 December 2022 Audience: General/trade , General Format: Paperback Publisher's Status: Active Availability: Manufactured on demand ![]() We will order this item for you from a manufactured on demand supplier. Table of ContentsReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |