Overview

Retroviruses have been of great importance to biomedical science for the past half century. Initially, studies on oncogenic animal retroviruses provided important insights into molecular processes in carcinogenesis - most notably the existence and mechanisms of action of oncogenes and proto-oncogenes. Moreover, several human diseases are caused by retroviruses, including AIDS, adult T-cell leukemia and the neurological disease HAM/TSP. The topic of this volume is a relatively unknown animal retrovirus, jaagsiekte sheep retrovirus, the causative agent of transmissible lung cancer in sheep ?ovine pulmonary adenocarcinoma. The disease was first documented in South Africa in the 1800s, it has a wide geographical distribution, and it is of economic importance in high endemic regions. However, until very recently the nature of the etiologic agent was unclear, and relatively few laboratories actively studied the disease.

Full Product Details

Author:   Hung Y. Fan
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   2003 ed.
Volume:   275
Dimensions:   Width: 15.50cm , Height: 1.50cm , Length: 23.50cm
Weight:   1.230kg
ISBN:  

9783540440963

ISBN 10:   3540440968
Pages:   254
Publication Date:   13 December 2002
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

A History of Ovine Pulmonary Adenocarcinoma (Jaagsiekte) and Experiments Leading to the Deduction of the JSRV Nucleotide Sequence.- Pathology of Ovine Pulmonary Adenocarcinoma.- Natural History of JSRV in Sheep.- Molecular Biology of Jaagsiekte Sheep Retrovirus.- Endogenous Retroviruses Related to Jaagsiekte Sheep Retrovirus.- Transformation and Oncogenesis by Jaagsiekte Sheep Retrovirus.- Identification of Hyal2 as the Cell-Surface Receptor for Jaagsiekte Sheep Retrovirus and Ovine Nasal Adenocarcinoma Virus.- Enzootic Nasal Adenocarcinoma of Sheep and Goats.- Pathology of Human Bronchioloalveolar Carcinoma and Its Relationship to the Ovine Disease.

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