Overview

The Fifth Ir Gene Workshop was held at the Chase-Park Plaza Hotel, St. Louis, MO, August 28-31, 1982; 240 scientists participated in the Workshop. The man­ uscripts compiled in this book describe the state of the art concerning Ir genes. Although the notion of Ir Genes: Past, Present, and Future has not been ad­ dressed specifically by each author, the reader is certain to get this flavor from the contributions. In this Preface, we have tried to summarize some of the salient ob­ servations and discussions from the Workshop. The mUltiple genes of the I region have been defined traditionally by serolog­ ical analysis of intra-H-2 recombinant mice and the pattern of immune responses to certain antigens developed by these recombinant mice. The application of sev­ eral new techniques, such as gene cloning and DNA sequencing, production of T and B cell hybridomas, and development of cloned T cell lines has changed this tradition and introduced a new phase into the analysis of the I region, Ia antigens, and Ir genes.

Full Product Details

Author:   Carl W. Pierce ,  Susan E. Cullen ,  Judith A. Kapp ,  Benjamin D. Schwartz
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   1983 ed.
Volume:   4
Dimensions:   Width: 15.50cm , Height: 3.40cm , Length: 23.50cm
Weight:   2.390kg
ISBN:  

9780896030503

ISBN 10:   0896030504
Pages:   622
Publication Date:   21 March 1983
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Genetic Organization of I-Region Genes.- Chemistry of I-Region Gene Products and DNA Cloning of I-Region Gene Products.- Ir Gene Function: Cellular Site(s) and Mechanism(s) of Action.- The Role of Ia Antigens in Restricted Cell Interactions.- Lessons on Ir Genes Derived from T Cell Clones and T Cell Hybridomas.- Where From Here?.

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