Overview

Written in a clear and engaging style, and generously illustrated with superb computer graphics, Introduction to Protein Architecture is a textbook for second and third year undergraduate students and beginning post-graduate students, and will be of interest to all biological and medical scientists whose work touches on proteins. The structures and functions of proteins unlock the secrets inherent in genomes, including the human genome. The emphasis of this book is on protein architecture, on proteins as three-dimensional patterns. A new field, bioinformatics, has grown up around gene and protein sequences and structures. It has captured the interest of many scientists for its intellectual challenges, its potential for useful applications, and promising scope for careers. This book introduces the use of the World Wide Web in bioinformatics. Written by one of the leaders in this field, Introduction to Protein Architecture explains the general characteristics of proteins that underlie the vary great variety of folding patterns observed in nature. For specialists in structural biology, it contains the core of what they need to know. For students and workers in related disciplines undergraduates or beginning graduate students in biology, chemistry, medicine, bioinformatics, and related fields it contains what they will be able to apply to their own work. Topics treated include: Pattern and form in protein structure; The building blocks; The relationship between amino acid sequence and protein structure; Secondary, supersecondary and tertiary structure; Classifications and hierarchies of protein folding patterns; Protein evolution; How proteins change conformation (and why). To suit the needs of courses, each chapter includes recommended reading, lists of useful web sites, traditional exercises, and a new type of exercise called a weblem, for WEB-based probLEM.

Full Product Details

Author:   Arthur M. Lesk
Publisher:   Oxford University Press
Imprint:   Oxford University Press
Dimensions:   Width: 18.90cm , Height: 2.30cm , Length: 24.60cm
Weight:   0.699kg
ISBN:  

9780198504740

ISBN 10:   0198504748
Pages:   360
Publication Date:   07 September 2000
Audience:   College/higher education ,  Tertiary & Higher Education
Format:   Paperback
Publisher's Status:   Out of Print
Availability:   Awaiting stock  

Table of Contents

CHAPTER 1: THE PHOTOSYNTHETIC REACTION CENTRE: PROTEIN STRUCTURE IN A MICROCOSM; The reaction centre from Rhodopseudomonas viridis; Conclusions; Recommended reading and references; Exercises and problems; CHAPTER 2: IN VIVO, IN VITRO, IN SILICO; Why study proteins?; Protein structure and conformation; The known protein sequences; The protein data bank; The World-Wide Web; Summary; Glossary; Useful Web sites; Recommended reading and references; Exercises, problems and weblems; CHAPTER 3: PATTERN AND FORM IN PROTEIN STRUCTURE; Helices and sheets; The heirarchical nature of protein architecture; An album of small structures; Classification of protein structures; Loops; Protein-ligand interactions; Useful Web sites; Recommended reading and references; Exercises, problems, and weblems; CHAPTER 4: THE VARIETIES OF PROTEIN STRUCTURE; Catalogues of protein structure; The known structures; alpha-helical proteins; beta-sheet proteins; alpha + beta proteins; alpha/beta proteins; Closed beta-alpha-beta barrel structures; Irregular structures; Conclusions; Useful web sites; Recommended reading and references; Exercises, problems, and weblems; CHAPTER 5: MOLECULAR EVOLUTION; Evolution of protein structures; Structural relationships among related molecules; Useful web sites; Recommended reading and references; Exercises, problems, and weblems; CHAPTER 6: EVOLUTION IN SELECTED PROTEIN FAMILIES; Evolution of the globins; Evolution of serine proteinases of the chymotrypsin family; NAD-binding domains of dehydrogenases; Useful web sites; Recommended reading and references; Exercises, problems, and weblems; CHAPTER 7: SOME PROTEINS OF THE IMMMUNE SYSTEM; Antibody structure; Proteins of the Major Histocompatibility Complex; T cell receptors; Useful web sites; Recommended reading and references; Exercises, problems, and weblems; CHAPTER 8: CONFORMATIONAL CHANGES IN PROTEINS; Structural changes arising from change in state of ligation; Hinge motions in proteins; The helix interface shear mechanism of conformational change; The allosteric change in haemoglobin; Serpins: SERine Proteinase Inhibitors; Higher-level structural changes; INDEX

Reviews

This is truly a monument to the architecture of proteins: a gorgeous tour of the structures that dwell within us. The frozen music of biology is clearly presented in beautiful detail. The text should be considered for any introductory graduate level course in biochemistry.

"This is truly a monument to the architecture of proteins: a gorgeous tour of the structures that dwell within us. The ""frozen music"" of biology is clearly presented in beautiful detail. The text should be considered for any introductory graduate level course in biochemistry."

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