Overview

Introduction to Nuclear Mechanics and Genome Regulation provides a detailed discussion of the biophysical principles underlying nuclear organization and their role in determining tissue function, cell differentiation and homeostasis, and disease expression and management. Applied case studies and full cover images support concept illustration across a diverse range of chapters covering physico-chemical constraints in DNA, 3D organization of chromosomes and functional gene clusters, spatial dimensions of DNA transcription, replication, damage and repair, and more. With its practical approach and foundational focus, this book will be an invaluable reference for students, researchers and clinicians looking to understand this area of cutting-edge study.

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9780128123454

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Dr. G. V. Shivashankar is currently the Deputy Director of Mechanobiology Institute, National University of Singapore. Shivashankar's laboratory is focused on understanding the role of cell geometry on nuclear mechanics and genome regulation in living cells using a multi-disciplinary approach. He carried out his PhD research at the Rockefeller University (1994-1999) and Postdoctoral research at NEC Research Institute, Princeton, USA (1999-2000). He started his laboratory at the National Center for Biological Sciences, TIFR- Bangalore, India (2000-2009) before relocating to a tenured faculty position at the National University of Singapore in 2009. His scientific awards include the Birla Science Prize (2006) and the Swarnajayanthi Fellowship (2007), and he was elected to the Indian Academy of Sciences (2010). He also edited a Methods in Cell Biology volume on Nuclear Mechanics and Genome Regulation (2010), published by Elsevier. More recently, he headed the Joint Research Laboratory with the FIRC Institute of Molecular Oncology (IFOM), Milan, Italy and was appointed as an IFOM-NUS Chair Professor in 2014.

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