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OverviewThis text examines in vitro cytotoxicology, which offers new methodologies to toxicity testing. This discipline of modern toxicology is gaining increasing acceptance as a viable alternative to traditional testing methods. The text discusses the application of in vitro cytotoxicology to toxicity testing and human risk assessment, and analyzes the advantages and limitations of the tests performed under scientific and regulatory conditions. The book also reviews the optimum utilization of certain tests for specific groups of chemicals relevant to validation programmes currently in progress. The text summarizes in vitro toxicity testing and other cell culture methods; presents prevailing mechanisms of in vitro cytotoxicology and cellular toxicity; and examines testing strategies, the role of validation, and the advantages and limitations of extrapolating data from in vitro testing to human cytotoxicology potential. Full Product DetailsAuthor: Frank A. Barile (St. John's University, Queens, New York, USA)Publisher: Taylor & Francis Inc Imprint: CRC Press Inc Dimensions: Width: 15.60cm , Height: 1.60cm , Length: 23.50cm Weight: 0.567kg ISBN: 9780849386596ISBN 10: 0849386594 Pages: 240 Publication Date: 09 February 1994 Audience: College/higher education , Professional and scholarly , Postgraduate, Research & Scholarly , Professional & Vocational Format: Hardback Publisher's Status: Out of Print Availability: Out of stock  Table of ContentsCell Culture Methodology and Its Application to In Vitro Cytotoxicology Mechanisms of Cytotoxicology Cellular Methods of General Toxicity Cellular Methods of Target-Organ Toxicity Cellular Methods of Local Toxicity Cellular Methods of Teratogenicity Cellular Methods of Immune Function Pharmacokinetic Studies in Cellular Systems Cellular Methods of Genotoxicity and Carcinogenicity, T.W. Sawyer Experimental Design and Statistics Standardization and Validation, B. Ekwall, F.A. Barile Cell Culture or Animal Toxicity Tests? Or Both? Index.ReviewsThis excellent little book truly lives up to its title, and I strongly recommend it as a book that should be in every in vitro toxicology laboratory. Those with experience in the field will be able to say that it will be useful for their new students, but the wiser among them will into it and admit that it provides many new ideas and insights. Michael Balls, As Quoted in the Journal Alternatives to Laboratory Animals Volume 22, No. 5, September/October 1994 Author InformationTab Content 6Author Website:Countries AvailableAll regions |
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