Overview

Introduction to Bioinformatics: A Theoretical and Practical Approach was written as an introductory text for the undergraduate, graduate, or professional. This text provides scientists with both a biological framework to understand the questions life scientist confront in the context of the computational issues and tools that are currently available for scientific research It also provides the life scientist with a resource to the various computational tools that are available all supported with their underlying mathematical foundations. The book is divided into four main sections. The first two sections provide an overview of the various biological processes that govern an organism and impact health. The first section, Biochemistry, Cell and Molecular Biology, describes basic cellular structure and the decoding of the genome. The second section, Molecular Genetics covers the regulation of genomes and the molecular genetic basis of disease as a consequence of genetic replication. Clinical human genetics and the various clinical databases are also reviewed. The third section, the Unix Operating System, demystifies the Unix system used throughout the world to support advanced computation tools. In addition to information on the installation and management of Unix-based software tools, examples of command line sequence analyses are presented that will enable the research to become as comfortable in a command-line environment as they are in the Graphical-User Interface environment. The final section, Computer Applications, provides information on the management and analysis of DNA sequencing projects, along with a review of how DNA can be modeled as a statistical series of patterns. It follows with a discussion of the various genome databases, the representation of genomes, and methods for their large scale analyses. Protein visualization, and transcription profiling including the use of analysis software for systems biology round out the coverage. The volume also includes a bonus CD-ROM, with a complete set of color illustrations from each chapter that will prove invaluable for professors preparing their next bioinformatics course or seminar. It also includes limited trial versions of the programs discussed in the text and encompass a broad spectrum from DNA sequencing project management to microarray analysis, thus offering the reader the opportunity to easily access the tools that are covered in the text.

Full Product Details

Author:   Stephen A. Krawetz ,  David D. Womble ,  David D. Womble
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   2003 ed.
Dimensions:   Width: 17.80cm , Height: 4.10cm , Length: 25.40cm
Weight:   3.670kg
ISBN:  

9781588290649

ISBN 10:   1588290646
Pages:   746
Publication Date:   31 January 2003
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of print, replaced by POD  
We will order this item for you from a manufatured on demand supplier.

Table of Contents

Part I. Biochemistry, Cell, and Molecular Biology A. The Cell Nucleic Acids and Proteins: Modern Linguistics for the Genomics and Bioinformatics Era Bradley C. Hyman Structure and Function of Cell Organelles Jon Holy Cell Signaling Daniel A. Rappolee B. Transcription and Translation DNA Replication, Repair, and Recombination Linda B. Bloom Transcription, RNA Processing, and Translation Thomas P. Yang and Thomas W. O'Brien Part II. Molecular Genetics A. Genomics Epigenetic Mechanisms Regulating Gene Expression John R. McCarrey Gene Families and Evolution Ben F. Koop Repetitive DNA: Detection, Annotation, and Analysis Jerzy Jurka Molecular Genetics of Disease and the Human Genome Project Paromita Deb-Rinker and Stephen W. Scherer B. Clinical Human Genetics Heredity C. A. Rupar The Clinical Genetics Databases Peter J. Bridge Population Genetics Jill S. Barnholtz-Sloan Part III. The UNIX Operating System A. Basics and Installation Introduction to UNIX for Biologists David D. Womble Installation of the Sun Solaris™ Operating Environment Bryon Campbell Sun System Administration Bryon Campbell B. Managing Bioinformatics Tools Installing Bioinformatics Software in a Server-Based Computing Environment Brian Fristensky Management of a Server-Based Bioinformatics Resource Brian Fristensky C. Command Line Sequence Analysis GCG File Management Sittichoke Saisanit GCG Sequence Analysis Sittichoke Saisanit Part IV. Computer Applications A. Management and Analysis of DNA Sequencing Projects and Sequences Managing Sequencing Projects in the GAP4 Environment Rodger Staden, David P. Judge, and James K. Bonfield OLIGO Primer Analysis Software John D. Offerman and WojciechRychlik Statistical Modeling of DNA Sequences and Patterns Gautam B. Singh Statistical Mining of the Matrix Attachment Regions in Genomic Sequences Gautam B. Singh Analyzing Sequences Using the Staden Package and EMBOSS Rodger Staden, David P. Judge, and James K. Bonfield B. The Genome Database: Analysis and Similarity Searching Ensembl: An Open-Source Software Tool for Large-Scale Genome Analysis James W. Stalker and Anthony V. Cox The PIR for Functional Genomics and Proteomics Cathy H. Wu Sequence Similarity and Database Searching David S. Wishart GCG Database Searching David J. Heard C. Identifying Functional and Structural Sequence Elements Pattern Discovery: Methods and Software Brona Brejová, Tomás Vinar, and Ming Li The Role of Transcription Factor Binding Sites in Promoters and Their In Silico Detection Thomas Werner An Introduction to Multiple Sequence Alignment and Analysis Steven M. Thompson 3D Molecular Visualization with Protein Explorer Eric Martz Multiple Sequence Alignment and Analysis: The SeqLab Interface: A Practical Guide Steven M. Thompson D. Analysis of Gene Expression: Microarrays and Other Tools Overview of the Tools for Microarray Analysis: Transcription Profiling, DNA Chips, and Differential Display Jeffrey A. Kramer Microarrays: Tools for Gene Expression Analysis Sorin Draghici Knowledge Discovery from the Human Transcriptome Kousaku Okubo and Teruyoshi Hishiki Part V. Appendices Appendix 1: CD Contents Appendix 2: A Collection of Useful Bioinformatic Tools and Molecular Tables Appendix 3: Simple UNIX Commands Index

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...contains very valuable information on a wide range of topics related to bioinformatics research. - Heredity

contains very valuable information on a wide range of topics related to bioinformatics research. Heredity

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