Overview

Recent research has focused attention on the importance of intrinsic antiviral immunity, i.e. immunity mediated by factors that are constitutively expressed in many cells. In this volume, leading experts provide a comprehensive overview of this relatively new and rapidly evolving field. They cover intrinsic proteinaceous antiviral immune effectors, such as the APOBEC3 and TRIM protein families as well as Tetherin and SAMHD1, which were initially discovered by researchers studying HIV-1. Furthermore, the role of RNA interference in antiviral defense in plants and invertebrates, as well as the interplay between microRNAs and viruses in mammalian cells, are analysed. One chapter discusses how intrinsic immunity and viral countermeasures to intrinsic immune effectors drive both pathogen and host evolution, and finally the emerging evidence that DNA damage response proteins restrict infection by DNA viruses is highlighted.  

Full Product Details

Author:   Bryan R. Cullen
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   2013 ed.
Volume:   371
Dimensions:   Width: 15.50cm , Height: 1.40cm , Length: 23.50cm
Weight:   4.161kg
ISBN:  

9783642427633

ISBN 10:   3642427634
Pages:   262
Publication Date:   16 June 2015
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

The APOBEC3 Family of Retroelement Restriction Factors Eric W. Refsland and Reuben S. Harris   Inhibition of Retroviral Replication by Members of the TRIM Protein Family Adam J Fletcher and Greg J Towers   The Antiviral Activities of Tetherin Stuart J D Neil   Restriction of Retroviral Infection of Macrophages Mark Sharkey   Rapid Adversarial Co-Evolution of Viruses and Cellular Restriction Factors Welkin E. Johnson   RNA Interference-Mediated Intrinsic Antiviral Immunity in Plants Szittya György and József Burgyán   RNA Interference-Mediated Intrinsic Antiviral Immunity in Invertebrates Arabinda Nayak, Michel Tassetto, Mark Kunitomi and Raul Andino   Roles of MicroRNAs in the Life Cycles of Mammalian Viruses Eva Gottwein   Interplay Between DNA Tumor Viruses and the Host DNA Damage Response Karyn McFadden and Micah Luftig

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