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OverviewIntermediate filaments are a large family of proteins that are the cytoskeletal elements involved in a number of skin, liver, neuromuscular, cardiac, eye and hair diseases. Intermediate filament genes are regulated in a tissue-and cell type-specific manner and their polymerized protein products protects the cells and tissue they are part of against a variety of mechanical and nonmechanical stresses. This book provides a comprehensive resource of methodology essentials, describing a variety of essential tools and assays for studying intermediate filaments. The book provides user-friendly advice and protocols covering all aspects of intermediate filaments including protein isolation and structure, protein and gene regulation, relationship to disease and apoptosis, and associated proteins. Both mammalian and non-mammalian systems and animal models are covered, making this book a must-have for any investigator wishing to study IF genes or their protein products. Full Product DetailsAuthor: M. Bishr Omary (Palo Alto VA Medical Center, Stanford University, Palo Alto, California, U.S.A.) , Pierre A. Coulombe (Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A.)Publisher: Elsevier Science Publishing Co Inc Imprint: Academic Press Inc Volume: 78 Dimensions: Width: 19.10cm , Height: 3.80cm , Length: 23.50cm Weight: 1.740kg ISBN: 9780125641739ISBN 10: 0125641737 Pages: 855 Publication Date: 18 December 2004 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: Out of stock  The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available. Table of ContentsReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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