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OverviewIntegrative Omics in Parkinson’s Disease provides a comprehensive understanding of the current literature on high-throughput technologies relating to discoveries for Parkinson's disease etiology. This emerging field uses large omics datasets to investigate the etiology of Parkinson’s disease and other forms of parkinsonism. The book traces the evolution of omics technologies from the discovery of monogenic Parkinson's disease forms. Chapters delve into genomics, transcriptomics, epigenomics, artificial intelligence, and gene-environment interactions. Furthermore, it examines the potential therapeutic applications of these advancements and provides insights into the future of omics research in Parkinson's disease. Full Product DetailsAuthor: Joanne Trinh, PhD (Institute of Neurogenetics, University of Lübeck, Germany)Publisher: Elsevier Science Publishing Co Inc Imprint: Academic Press Inc Weight: 0.450kg ISBN: 9780443135507ISBN 10: 0443135509 Pages: 274 Publication Date: 24 September 2024 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of Contents1. Introduction: evolution of omics 2. Monogenic and Complex genetics PD 3. Genetic risk scores 4. Somatic mosaic variants 5. Structural variant detection 6. Mitochondrial genetics 7. Epigenetics in PD genes 8. Single-cell sequencing 9. The microbiome 10. Exposome biology in PD 11. Genetic modifiers in reduced penetrance: X-linked dystonia parkinsonism as a model 12. Long-read transcriptomics in neurodegeneration 13. Gene-environment interactions and behavior 14. Application of artificial IntelligenceReviewsAuthor InformationJoanne Trinh, Ph.D., is a Heisenberg professor at the Institute of Neurogenetics, University of Lübeck. Dr. Joanne Trinh received her doctorate in medical genetics at the University of British Columbia. She subsequently joined the Institute of Neurogenetics in Lübeck, where she obtained a faculty position. She is now head of the “Integrative Omics in Parkinson’s Disease research group, which investigates the role of mosaic variants, nuclear and mitochondrial genome sequences, and lifestyle and environmental factors in parkinsonism. She is on the editorial board of Annals of Neurology and an associate editor of Frontiers in Neurology. Her research group in Lübeck will continue to use big-data approaches to elucidate the causes of neurological disease. Tab Content 6Author Website:Countries AvailableAll regions |
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