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OverviewA new human in vitro anti-angiogenesis assay was established and applied to identify novel angiopreventive agents. Subsequently, two chemopreventive compounds, xanthohumol (XN) from Humulus lupu-lus L. (hop) and sulforaphane (SFN), an isothiocyanate derived from cruciferous vegetables (Brassicaceae), were selected for detailed in-vestigation of their angiopreventive potential and mechanisms invol-ved in the inhibition of angiogenesis. Representative targets included effects at the transcriptional levels of pro-angiogenic factors, anti-gelatinolytic and anti-endothelial activity. In vivo, XN was shown to exhibit a strong anti-tumour potency on human breast cancer xeno-grafts mediated by the inhibition of tumour-induced angiogenesis. These findings strongly suggest that XN and SFN represent attractive chemopreventive lead structures possessing a remarkable potential to prevent tumour development. Full Product DetailsAuthor: Elisabeth KlenkePublisher: VDM Verlag Dr. Mueller E.K. Imprint: VDM Verlag Dr. Mueller E.K. Dimensions: Width: 15.20cm , Height: 0.70cm , Length: 22.90cm Weight: 0.186kg ISBN: 9783639036305ISBN 10: 3639036301 Pages: 132 Publication Date: 04 June 2008 Audience: General/trade , General Format: Paperback Publisher's Status: Active Availability: In Print  This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of ContentsReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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