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OverviewThis volume details our current understanding of the architecture and signaling capabilities of known canonical and non-canonical inflammasome complexes and highlights their action, in particular in response to infection with important bacterial model organisms and the corresponding disease pathologies. The first chapters review new insights into the assembly and structures of inflammasome components and emphasize general strategies of up- and downstream signaling events. In addition, the authors specifically discuss the composition and activity of inflammasomes during infection with various gut pathogens (Salmonella, Shigella, Yersinia, Listeria and Helicobacter), respiratory pathogens (Mycobacterium, Legionella, Burkholderia and Streptococcus) as well as skin and soft tissue pathogens (Francisella and Staphylococcus). The discoveries presented provide a better understanding of the cellular and molecular biology of inflammasomes, which will pinpoint important new therapeutic targets for the treatment and prevention of multiple infectious diseases in the future. It is a valuable resource for students, scientists and clinicians, providing up-to-date information on this emerging research topic. Full Product DetailsAuthor: Steffen BackertPublisher: Springer International Publishing AG Imprint: Springer International Publishing AG Edition: 1st ed. 2016 Volume: 397 Dimensions: Width: 15.50cm , Height: 1.80cm , Length: 23.50cm Weight: 5.679kg ISBN: 9783319411705ISBN 10: 3319411705 Pages: 282 Publication Date: 08 August 2016 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of ContentsGeneral strategies in inflammasome biology (overview).- Structural mechanisms in inflammasome assembly and signaling.- Salmonella enterica inflammasome.- Yersinia pestis inflammasome.- Shigella flexneri inflammasome.- Helicobacter pylori inflammasome.- Listeria monocytogenes inflammasome.- Legionella pneumophila inflammasome.- Mycobacterium inflammasome.- Burkholderia pseudomallei inflammasome.- Streptococcus pneumoniae inflammasome.- Franciscella tularensis inflammasome.- Staphylococcus aureus inflammasome.ReviewsAuthor InformationSteffen Backert is a professor at Erlangen/Nuremberg University (Germany), Chair of Microbiology. Tab Content 6Author Website:Countries AvailableAll regions |
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