Overview

Since 1980 there has been an accumulation of new information concerning DNA-damage-inducible processes in eukaryotic cells. It is clear that changes in the concentrations of activities of specific protein molecules play central roles in toxicological response of cells to chemical and radiation damage to DNA. Identification of inducible proteins may be crucial in helping to explain target organ toxicity and species differences. Detection of these proteins or their mRNA's in humans may be useful in assessing human exposure or cellular injury. Written by leading professionals who have extensive experience in the mutagenic/carcinogenic area, the aim of this monograph is to examine the responsiveness of eukaryotic cells to a variety of environmental toxicants. In particular, this text's ten chapters are devoted to the response seen at the molecular (gene, chromosome, DNA) level. The emphasis is placed on the toxic agents rather than the genetic process. It is aimed at toxicologists, specifically genetic toxicologists, radiation researchers and graduate students doing research in this area, and people dealing in risk assessment.

Full Product Details

Author:   Toby G Rossman
Publisher:   Taylor & Francis Inc
Imprint:   CRC Press Inc
Dimensions:   Width: 17.80cm , Height: 1.20cm , Length: 25.40cm
Weight:   0.553kg
ISBN:  

9781560322726

ISBN 10:   1560322721
Pages:   180
Publication Date:   21 September 1992
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Xenobiotic Regulation Of Glutathione S-Transferase Ya Gene Expression; induction of a novel damage-specific DNA binding protein correlates with enhanced DNA repair in primate cells; repair of alkylated bases in mammalian cells; modulation in response to DNA-damaging agents; modification in DNA ligase activity during DNA repair in mammalian cells; Cell-Cycle And DNA-Damage Regulation Of Ribonucleotide Reductase In saccharomyces cerevisiae; review - gene amplification - a cellular response to genotoxic stress; carcinogen-inducible proteins as mediators of asynchronous replication of DNA tumor viruses; carcinogen-induced gene amplification and gene expression; gadd153, a growth arrest and DNA- damage-induced gene - expression in response to genotoxic stress; ultraviolet irradiation and phorbol esters induce gene transcription by different mechanisms. Part contents.

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