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Author:   Jose V. Castell (University Hospital 'La Fe', Valencia, Spain) ,  Maria Jose Gmez-Lechn (University Hospital 'La Fe', Valencia, Spain) ,  Maria Jose Gmez-Lechn
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Dimensions:   Width: 16.50cm , Height: 2.60cm , Length: 24.10cm
Weight:   1.030kg
ISBN:  

9780121633905

ISBN 10:   012163390
Pages:   467
Publication Date:   04 October 1996
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

D.W. Straughan, J.H. Fentem, and M. Balls, Replacement Alternative and Complementary In Vitro Methods in Pharamaceutical Research. M.D. Barratt and M. Chamberlain, Integration of QSAR and In Vitro Toxicology. F.A. Barile, Continuous Cell Lines as a Model for Drug Toxicity Assessment. P. Bach, In Vitro Models for Nephrotoxicity Studies. A.E.M. Vickers, Experimental In Vitro Models to Evaluate Hepatotoxicity. M.J. Gomez-Lechon, T. Donato, X. Ponsoda, R. Fabra, R. Trullenque, and J.V. Castell, Isolation, Culture and Use of Human Hepatocytes in Drug Research. E. McFarlane-Abdulla, and I.C. Campbell, Studies of Nephrotoxicity in Cellular Studies. M. Adolphe, S. Thenet-Gauci, and S. Demignot, Chondrocyte Culture: A Target System to Evaluate Pharmaco-Toxicological Effects of Drugs. E. Chacon, D. Acosta, and J.J. Lemasters, Primary Cultures of Cardiac Myocytes as In Vitro Models for Pharmacological andToxicological Assessments. R. Roguet, Cutaneous Pharmacotoxicology In Vitro. H. Spielmann, Ocular Irritation. M.A. Miranda, Phototoxicity of Drugs. I. de G. Mitchell and R.D. Combes, In Vitro Genotoxicity and Cell Transformation Assessment. B. Schmid, R. Bechter, and P. Kucera, The Use of Whole Embryo Cultures in In Vitro Teratogenicity Testing. J.V. Castell, M.J. Gomez-Lechon, X. Ponsoda, and R. Bort, In Vitro Investigation of the Molecular Mechanisms of Hepatotoxicity. A. Guillouzo, Biotransformation of Drugs by Hepatocytes. K. Mace, E.A. Offord, and A.M.A. Pfeifer, Drug Metabolism and Carcinogen Activation Studies with Human Genetically Engineered Cells.

Reviews

A compilation of in-depth chapters. This volume makes an important and significant contribution to the field. --ALAN M. GOLDBERG, PhD, Director, Centre for Alternatives to Animal Testing, Johns Hopkins University

"""A compilation of in-depth chapters. This volume makes an important and significant contribution to the field."" --ALAN M. GOLDBERG, PhD, Director, Centre for Alternatives to Animal Testing, Johns Hopkins University"

Author Information

J.V. Castell is a member of the Scientific Advisory Board of the European Union's Centre for the Validation of Alternative Methods (ECVAM).

Tab Content 6

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