Overview

Bacterial CpG-DNA sequences not only serve for genetic information but act as danger signal to alert immune cells such as macrophages and dendritic cells. CpG-DNA directly causes activation of these members of the innate immune system yielding in up-regulation of co-stimulatory molecules and pro-inflammatory cytokines. As such they act as natural adjuvants to promote protective Th1 polarized T cell immune responses. This book reviews the data emerging in this field.

Full Product Details

Author:   Hermann Wagner (Technische Universitat Munich, Germany)
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   illustrated edition
Volume:   v.247
Weight:   0.500kg
ISBN:  

9783540664000

ISBN 10:   3540664009
Pages:   255
Publication Date:   08 December 1999
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Temporarily unavailable  
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Table of Contents

Mechanism of Action of CpG DNA.- Oligodeoxyribonucleotides with 5'-ACGT-3' or 5'-TCGA-3' Sequence Induced Production of Interferons.- Macrophage Activation by Immunostimulatory DNA.- Consequences of Bacterial CpG DNA-Driven Activation of Antigen-Presenting Cells.- Signal Transduction Pathways Activated by CpG-DNA.- CpG DNA Co-Stimulated Antigen-Reactive T Cells.- Role of Type I Interferons in T Cell Activation Induced by CpG DNA.- Hematopoietic Remodelling Triggered by CpG DNA.- CpG DNA Augments the Immunogenicity of Plasmid DNA Vaccines.- The Role of Bacterial DNA in Autoantibody Induction.- CpG DNA in Cancer Immunotherapy.- Use of CpG DNA for Enhancing Specific Immune Responses.- Immunostimulatory-Sequence DNA is an Effective Mucosal Adjuvant.- CpG DNA Switches on Th1 Immunity and Modulates Antigen-Presenting Cell Function.- Effects of CpG DNA on Th1/Th2 Balance in Asthma.- Responses of Human B Cells to DNA and Phosphorothiase Oligodeoxynucleotides.

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