Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation: Models in Discovery and Translation

Author:   Gerard Socie (Department Head, Transplantation Program AP-HP, Hospital Saint Louis, Paris CEDEX 10, France University Paris VII Denis Diderot) ,  Robert Zeiser (Heisenberg Professor and Consultant Physician, Department of Hematology and Oncology, University Medical Center Freiburg, Germany) ,  Bruce R. Blazar
Publisher:   Elsevier Science Publishing Co Inc
Edition:   2nd edition
ISBN:  

9780128126301


Pages:   430
Publication Date:   07 November 2018
Format:   Hardback
Availability:   Not yet available   Availability explained
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Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation: Models in Discovery and Translation


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Author:   Gerard Socie (Department Head, Transplantation Program AP-HP, Hospital Saint Louis, Paris CEDEX 10, France University Paris VII Denis Diderot) ,  Robert Zeiser (Heisenberg Professor and Consultant Physician, Department of Hematology and Oncology, University Medical Center Freiburg, Germany) ,  Bruce R. Blazar
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Edition:   2nd edition
ISBN:  

9780128126301


ISBN 10:   0128126302
Pages:   430
Publication Date:   07 November 2018
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Forthcoming
Availability:   Not yet available   Availability explained
This item is yet to be released. You can pre-order this item and we will dispatch it to you upon its release.

Table of Contents

1. Overview 2. HLA system 3. Minor Ag 4. In vivo imaging 5. Engraftment, graft rejection and graft failure 6. Immune regeneration or immune recovery 7. Tumor associated antigens 8. Genetically engineered T cell therapies and immune system engagers for GVHD and GvL 9. Microbiome 10. micro-RNA and kinase regulatory mechanisms and pathways in GVHD 11. APC 12. Costimulation vs. Inhibition 13. Th1/2 & TC1/2 14. Treg 15. Th17 16. B and T cells in chronic GVHD 17. NK 18. Cytokines 19. Chemokines 20. Metabolism and intracellular sensor 21. Omics 22. Endothelium and stroma 23. Future

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Dr. Gerard Socie's main field of expertise (clinical and biological); allogeneic stem cell transplantation with special focus on graft-versus-host disease and study of late effects, aplastic anemia with special focus on PNH, and Fanconi anemia. He is GCP certified (last May 2017) and the department head and head of transplantation at the Hospital Saint Louis, University of Paris VII. Prof. Robert Zeiser serves as Full Professor of Medicine at the Department of Hematology, Oncology and Stem Cell Transplantation Medical Center, University of Freiburg in Germany and his work can be divided into clinical responsibilities, clinical and laboratory-based research and teaching activities. Prof. Zeisers laboratory research is focused on graft-versus-host disease, tumor biology, in vivo imaging and signaling. In particular his groups has used different imaging techniques including Bioluminescence imaging, Magnetic resonance imaging, Fluorescence imaging and Positron emission tomography/CT imaging to monitor the fate of different cell types in living animals. His group has made major contributions to the field of pre-clinical and clinical research with publications in Nature Medicine, J Ex Med, Blood, New England Journal of Medicine and Journal of Clinical Investigation. Prof. Zeiser authors 130 peer-reviewed publications and 10 book chapters. For his work Prof. Zeiser received several Science Awards in Germany, Europe and the United States and research grants from multiple funding agencies. He has served as a reviewer for Science, Nature Medicine, Nature Immunology, Nature Methods, Nature Reviews Immunology, Nature Reviews Cancer, New England Journal of Medicine, Lancet Haematology, Blood and others. Prof. Zeiser is Section Editor of the Journal Blood and act as expert reviewer for research funding bodies in Germany, France, Israel, China, Netherlands, Austria, European Union, United Kingdom, Poland, Belgium and Switzerland. Also Prof. Zeiser was elected to serve as Deputy Director of the Collaborative Research Center SFB850 and as Director of the Division of Tumor immunology at the University of Freiburg in Germany.

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