|
|
|||
|
||||
OverviewEvents in meiosis are central to the formation of healthy sperms and egg cells. A defective meiosis is the largest genetic cause of infertility, pregnancy loss, stillbirths and severe birth defects. Only a fraction of genes involved in recombination and cell division have been identified so far. The goal of my research is to detect novel genes that are significantly involved in meiosis. To that end, I carried out a genetic screen and I have identified new mutants that confer defects in meiosis. The model organism that was utilized to investigate events in meiosis was the budding yeast. Mutations in the yeast genome were created by the integration of bacterial mini-transposon at random sites. The identified mutants exhibit particular phenotype that is dependent on incubation temperatures. Mutations in the identified candidates are confirmed by genetic approach. Thus far, from this insertional mutagenesis approach, three different kinds of mutants have been identified - (i) mutants carrying mutations in the open reading frames of genes, (ii) mutant carrying mutation in the intergenic region of yeast genome, and (iii) mutant carrying mutation in the 2µ-plasmid. Full Product DetailsAuthor: Sneharthi BanerjeePublisher: LAP Lambert Academic Publishing Imprint: LAP Lambert Academic Publishing Dimensions: Width: 15.20cm , Height: 0.70cm , Length: 22.90cm Weight: 0.177kg ISBN: 9783659472534ISBN 10: 3659472530 Pages: 112 Publication Date: 24 October 2013 Audience: General/trade , General Format: Paperback Publisher's Status: Active Availability: In stock We have confirmation that this item is in stock with the supplier. It will be ordered in for you and dispatched immediately. Table of ContentsReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |