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OverviewThe Signal Transducer and Activator of Transcription 1 (STAT1) is activated in response to interferons (IFNs) stimulations. In response to IFN-γ, STAT1 homodimerizes to form the gamma activating factor (GAF). In response to IFN-α, STAT1 heterotrimerizes with STAT2 and ISGF3-γ to form the interferon sequence gene factor 3 (ISGF3). This work clearly demonstrates the distinct roles of the IFN-γ-induced-GAF complexes in anti-mycobacterial immunity and of IFN-α induced- ISGF3 complexes in the anti-viral immunity in humans at the cellular and clinical levels by different molecular mechanisms. It also highlights the fact that a phenotype depends of the mutation and not only of the affected gene; and moreover the importance of the homozygosis or heterozygosis state of the mutation in human genetic diseases. Full Product DetailsAuthor: Ariane ChapgierPublisher: LAP Lambert Academic Publishing Imprint: LAP Lambert Academic Publishing Dimensions: Width: 15.20cm , Height: 0.80cm , Length: 22.90cm Weight: 0.209kg ISBN: 9783844301687ISBN 10: 3844301682 Pages: 136 Publication Date: 15 February 2011 Audience: General/trade , General Format: Paperback Publisher's Status: Active Availability: In stock  We have confirmation that this item is in stock with the supplier. It will be ordered in for you and dispatched immediately. Table of ContentsReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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