Overview

This unique book explores the role of retrotransposons in human health and disease. The ability of retrotransposons to affect the structure of human genes is recognized since the late 80’s. However, the advances of deep-sequencing technologies have shed new light on the extent of retrotransposon-mediated genome variations. These progresses have also led to the discovery that retrotransposon activity is not restricted to the germline - resulting in inheritable genetic variations - but can also mobilize in somatic tissues, such as embryonic stem cells, neuronal progenitor cells, or in many cancers. This book covers topics related to the effects of retrotransposon insertions, and their consequences on germline and somatic genome dynamics, but also discuss the role and impact of retrotransposons sequences in a broader context, including a number of novel topics that emerged recently (long non-coding RNA, neuronal disorders, exaptation) with unexpected connections between retrotransposons, stem cell maintenance, placentation, circadian cycles or aging.

Full Product Details

Author:   Gael Cristofari
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   Softcover reprint of the original 1st ed. 2017
Dimensions:   Width: 15.50cm , Height: 1.80cm , Length: 23.50cm
Weight:   0.522kg
ISBN:  

9783319839172

ISBN 10:   3319839179
Pages:   330
Publication Date:   07 July 2018
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

Retrotransposons and the Mammalian Germline.- L1 regulation in Mouse and Human Germ Cells.- Retrotransposon Contribution to Genomic Plasticity.- The Mobilization of Processed Transcripts in Germline and Somatic Tissues.- Neuronal Genome Plasticity: Retrotransposons, Environment and Disease.- Activity of Retrotransposons in Stem Cells and Differentiated Cells.- Environment, Cellular Signaling and L1 activity.- Retrotransposon-derived Regulatory Regions and Transcripts in Stemness.- Roles of Endogenous Retrovirus-encoded Syncytins in Human Placentation.- Alu-Alu Recombinations in Genetic Diseases.- Retrotransposon-driven Transcription and Cancer.- LINE-1 retrotransposons as Neoplastic Biomarkers.- Contribution of Retrotransposable Elements to Aging.

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Author Information

Gael Cristofari is a biomedical expert in Molecular Biology & Genetics and Biology & Biochemistry at IRCAN, in Nice, France.

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