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Overview8 References . 95 Subject Index 101 VIII 1 Introduction Mast cells and basophils were first described by Ehrlich (1877, 1878, 1879). Although these cells share many functional properties, they can readily be distinguished using morphological criteria (Dvorak 1986a; Dvorak et al. 1983a, 1983c; Galli et al. 1984). The identification of immunoglobulin E (IgE) and high affinity IgE receptors on mast cells and basophils was instrumental to our understanding of the mechanisms underlying the role of these cells in immediate hypersensitivity reactions (Ishizaka and Ishizaka 1979; Ishizaka et al. 1966, 1972, 1973; Tomioka and Ishizaka 1971). We now know that these IgE-mediated mechanisms as well as a number of other stimuli can cause the rapid release of many preformed mediators of inflammation from both mast cells and basophils (Galli et al. 1984). The most well-known of these is histamine. Potent mediators that are not preformed are also stimulated and released from these cells. Recently, products of arachidonic acid metabolism, such as the prostaglandins and leukotrienes, have been found to be generated either by the cyclooxygenase pathway or the lipoxy- genase pathway in mast cells and basophils (Lewis and Austen 1981, 1984; Peters et al. 1984, 1987). Detailed studies and reviews of the biochemistry of these mediators and their immunologically mediated reactions have been published (Lewis and Austen 1981, 1984; Lichtenstein et al. 1979; MacGlashan et al. 1982b; Paterson et al. 1976; Peters et al. 1984, 1987). Mast cells and basophils contain other important biochemicals. Full Product DetailsAuthor: Ann M. DvorakPublisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Imprint: Springer-Verlag Berlin and Heidelberg GmbH & Co. K Volume: 114 Dimensions: Width: 17.00cm , Height: 0.60cm , Length: 24.20cm Weight: 0.270kg ISBN: 9783540503743ISBN 10: 3540503749 Pages: 107 Publication Date: 24 April 1989 Audience: College/higher education , Professional and scholarly , Undergraduate , Postgraduate, Research & Scholarly Format: Paperback Publisher's Status: Active Availability: Out of stock  The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available. Table of Contents1 Introduction.- 2 Ultrastructure of Human Mast Cells.- 3 Ultrastructure of Human Basophils.- 4 In Vitro Studies of Human Mast Cells.- 4.1 Human Mast Cell Granules and Lipid Bodies.- 4.2 Anaphylactic Degranulation of Human Lung Mast Cells In Vitro.- 4.3 Recovery from Anaphylactic Degranulation of Human Lung Mast Cells In Vitro.- 5 In Vivo Studies of Human Mast Cells.- 5.1 Anaphylactic Degranulation of Human Mast Cells In Vivo.- 5.2 Piecemeal Degranulation of Human Mast Cells In Vivo.- 5.3 Activated Human Mast Cells Have Increased Lipid Bodies.- 5.4 Mast Cell Shedding.- 6 Mast Cell Morphologic Cycles.- 6.1 In Vitro.- 6.2 In Vivo.- 7 Concluding Remarks.- 8 Summary.- References.ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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