Overview

Presenting the first database of its kind, this unique reference illustrates the relationships between the chemistry and developmental toxicity of a number of important pharmaceuticals and industrial toxicants. Human Developmental Toxicants contains up-to-date and concise information on the chemical structures, properties, and biological activities for 50 known agents that adversely affect prenatal and postnatal human development in terms of growth, viability, structure, and function. This book presents data linking chemical and structural properties of specific toxicants as they relate to toxic effects, dosage, timing, and route of exposure. Focusing on one compound per chapter, the book also includes associated biological data from animals for each agent covered. Accompanying downloadable resources summarize all of the data discussed in the text within an electronic database. In addition, the CD contains three-dimensional structure representations and 49 calculated physicochemical and topological parameters of the selected molecules. This information is useful for building structure activity relationship (SAR) models linking the chemical properties with observed human developmental toxicity. As scientists continue to explore how chemicals alter human development, Human Developmental Toxicants contains the necessary information to further identify which chemical properties are responsible for adverse effects. This reference provides toxicologists, teratologists, chemists and other scientists with the latest data and information needed to perform risk assessments, predict chemicals that may produce developmental toxicity, and regulate harmful exposure.

Full Product Details

Author:   James L. Schardein ,  Orest T. Macina
Publisher:   Taylor & Francis Inc
Imprint:   CRC Press Inc
Dimensions:   Width: 17.80cm , Height: 2.90cm , Length: 25.40cm
Weight:   0.975kg
ISBN:  

9780849372292

ISBN 10:   0849372291
Pages:   456
Publication Date:   15 August 2006
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Aminopterin. Busulfan. Cyclophosphamide. Methotrexate. Chlorambucil. Mechlorethamine. Cytarabine. Tretinoin. Propranolol. Penicillamine. Vitamin A. Carbamazepine. Danazol. Paramethadione. Carbon Monoxide. Formaldehyde. Isotretinoin. Captopril. Misoprostol. Streptomycin. Methimazole. Ethylene Oxide. Tetracycline. Caffeine. Thalidomide. Primidone. Fluconazole. Ergotamine. Propylthiouracil. Medroxyprogesterone. Cocaine. Quinine. Methylene Blue. Warfarin. Phenobarbital. Trimethoprim. Methyltestosterone. Disulfiram. Valproic Acid. Carbon Disulfide. Norethindrone. Phenytoin. Etretinate. Toluene. Ethisterone. Acitretin. Valsartan. Diethylstilbestrol. Pseudoephedrine. Ethanol. Summary and Conclusions.

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Schardein, James L.; Macina, Orest T.

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