Overview

Although the utility of human antibodies as medical therapeutics for cancer and immune diseases has been well-established, it is only beginning to be realized for the treatment of viral infectious diseases. Polyclonal immunoglobulins have long been used for some viral diseases, but they have limited potency and disease scope. It should theoretically be possible to create monoclonal or oligoclonal antibody preparations that capture the essential curative functions of the humoral immune response to viral pathogens, yet only a single humanized monoclonal antibody (pavilizumab) has been approved as a viral countermeasure. Reliable technologies for creating human or humanized antibodies with defined viral antigen specificities are well-established. Accordingly, current antibody development efforts are focused on identifying and cloning the particular antibodies that contain the fundamental curative potency of the polyclonal humoral immune response.

Full Product Details

Author:   Scott K. Dessain
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of hardcover 1st ed. 2008
Volume:   317
Dimensions:   Width: 15.50cm , Height: 1.00cm , Length: 23.50cm
Weight:   0.320kg
ISBN:  

9783642091315

ISBN 10:   3642091318
Pages:   190
Publication Date:   30 November 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Out of stock  
The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available.

Table of Contents

Therapeutic Control of Hepatitis C Virus: The Role of Neutralizing Monoclonal Antibodies.- Antibodies for HIV Treatment and Prevention: Window of Opportunity?.- Human Monoclonal Antibody and Vaccine Approaches to Prevent Human Rabies.- Immunoprophylaxis of RSV Infection: Advancing from RSV-IGIV to Palivizumab and Motavizumab.- The Molecular Basis of Antibody Protection Against West Nile Virus.- Exploring the Native Human Antibody Repertoire to Create Antiviral Therapeutics.

Reviews

From the reviews: The articles in this book focus on the use of antibodies for the treatment of viral infectious diseases. ! The book is written for anyone who has an interest in vaccine development. An advanced graduate student would have no trouble understanding this information. ! For anyone interested in antibody therapeutics for viral diseases, this would be a useful book. The chapters are well written and detailed. The bibliography for each chapter is extensive. It would be a welcome addition to a department or school library. (Marion C. Cohen, Doody's Review Service, July, 2008)

From the reviews: The articles in this book focus on the use of antibodies for the treatment of viral infectious diseases. ... The book is written for anyone who has an interest in vaccine development. An advanced graduate student would have no trouble understanding this information. ... For anyone interested in antibody therapeutics for viral diseases, this would be a useful book. The chapters are well written and detailed. The bibliography for each chapter is extensive. It would be a welcome addition to a department or school library. (Marion C. Cohen, Doody,s Review Service, July, 2008)

Author Information

Tab Content 6

Author Website:  

Customer Reviews

Recent Reviews

No review item found!

Add your own review!

Countries Available

All regions