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OverviewFull Product DetailsAuthor: Marc Laurence Mendillo , David Pincus , Ruth Scherz-ShouvalPublisher: Springer Nature Switzerland AG Imprint: Springer Nature Switzerland AG Edition: 1st ed. 2020 Volume: 1243 Weight: 0.739kg ISBN: 9783030402037ISBN 10: 3030402037 Pages: 182 Publication Date: 16 April 2020 Audience: College/higher education , Professional and scholarly , Postgraduate, Research & Scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of ContentsPreface: Dedication to Susan Lindquist.- Part I: Structure.- Structural and Biochemical properties of Hsp40/Hsp70 chaperone system.- The TRiC/CCT chaperonin and its role in uncontrolled proliferation.- Regulation of Hsf1 and the heat shock response.- Part II: Function.- Challenging proteostasis: Role of the chaperone network to control aggregation-prone proteins in human disease.- The multifaceted role of HSF1 in tumorigenesis.- Chaperome networks – redundancy and implications for cancer treatment.- Chaperones in the tumor microenvironment.- The impact of the ER unfolded protein response on cancer initiation and progression: Therapeutic implications.- Part III: Therapies.- The right tool for the job: an overview of Hsp90 inhibitors.- Lessons learned from proteasome inhibitors, the paradigm for targeting protein homeostasis in cancer.- Reflections and outlook on targeting HSP90, HSP70 and HSF1 in cancer: A personal perspective.ReviewsDr. Ruth Scherz-Shouval professional and educational honors include an Aharon Katzir Center travel fellowship and the Feinberg Graduate School Dean's prize for PhD students in 2007, and a Sir Charles Clore Postdoctoral fellowship in 2008. In 2010, Dr. Scherz-Shouval won a Weizmann Institute of Science National Postdoctoral Award for Advancing Woman in Science, a Fulbright Postdoctoral Fellowship, and a Human Frontiers Scientific Program Long-Term Fellowship. She was awarded a Stuart fellowship for cancer research in 2011, and the AACR Scholar-in-Training Award supported by Susan G. Komen in 2014 Author InformationDr. Ruth Scherz-Shouval is the daughter of Prof. Avigdor Scherz, a pioneer in the field of photo-dynamic therapy in the Department of Plant and Environmental Sciences at the Weizmann Institute. She earned a BSc in the life sciences with honors at the Hebrew University of Jerusalem in 2002 and a PhD in biological chemistry at the Weizmann Institute of Science in 2008 (with Prof. Zvulun Elazar). She conducted postdoctoral research in Prof. Moshe Oren’s laboratory at the Weizmann Institute and at the Whitehead Institute for Biomedical Research at the Massachusetts Institute of Technology (MIT), and will join the Weizmann Institute’s Department of Biological Chemistry in October 2015. Dr. Marc Mendillo is an Assistant Professor of Biochemistry and Molecular Genetics at the Northwestern University. His PhD was obtained from the University Of California-San Diego in Biomedical Sciences followed by a Postdoctoral Fellowship at the Ludwig Institute for Cancer Research in San Diego and another at the Whitehead Institute. Currently, he runs a lab in the Department of Biochemistry and Molecular Genetics and the Robert H. Lurie Comprehensive Cancer Center. Dr. David Pincus is a fellow at the Whitehead Institute where he tries to reveal the underlying mechanisms cells employ to maintain homeostasis in inherently fluctuating environments. Tab Content 6Author Website:Countries AvailableAll regions |
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